A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.

<h4>Purpose</h4>To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC) patients.<h4>Methods and materials</h4>Fifty eight NPC patients with radiation-induced te...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jianhong Ye, Xiaoming Rong, Yanqun Xiang, Yigang Xing, Yamei Tang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/004d2a533905410a8d090cda9c1a8c63
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:004d2a533905410a8d090cda9c1a8c63
record_format	dspace
spelling	oai:doaj.org-article:004d2a533905410a8d090cda9c1a8c632021-11-18T07:08:56ZA study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.1932-620310.1371/journal.pone.0042890https://doaj.org/article/004d2a533905410a8d090cda9c1a8c632012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912759/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC) patients.<h4>Methods and materials</h4>Fifty eight NPC patients with radiation-induced temporal lobe necrosis (TLN) were recruited in the study. Duplex ultrasonography was used to scan bilateral carotid arterials to evaluate the intima-media thickness (IMT) and occurrence of plaque formation. Flow velocities of bilateral middle cerebral arteries (MCAs), internal carotid arteries (ICAs) and basal artery (BA) were estimated through Transcranial Color Doppler (TCD). The results were compared with data from 33 patients who were free from radiation-induced temporal lobe necrosis after radiotherapy and 29 healthy individuals.<h4>Results</h4>Significant differences in IMT, occurrence of plaques of ICAs and flow velocities of both MCAs and ICAs were found between patients after radiotherapy and healthy individuals (p<0.05). IMT had positive correlation with post radiation interval (p = 0.049). Compared with results from patients without radiation-induced TLN, the mean IMT was significantly thicker in patients with TLN (p<0.001). Plaques were more common in patients with TLN than patients without TLN (p = 0.038). In addition, flow velocities of MCAs and ICAs in patients with TLN were much faster (p<0.001, p<0.001). Among patients with unilateral TLN, flow velocity of MCAs was significantly different between ipsilateral and contralateral sides to the lesion (p = 0.001).<h4>Conclusion</h4>Thickening of IMT, occurrence of plaque formation and hemodynamic abnormality are more common in patients after radiotherapy, especially in those with TLN, compared with healthy individuals.Jianhong YeXiaoming RongYanqun XiangYigang XingYamei TangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42890 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianhong Ye Xiaoming Rong Yanqun Xiang Yigang Xing Yamei Tang A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
description	<h4>Purpose</h4>To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC) patients.<h4>Methods and materials</h4>Fifty eight NPC patients with radiation-induced temporal lobe necrosis (TLN) were recruited in the study. Duplex ultrasonography was used to scan bilateral carotid arterials to evaluate the intima-media thickness (IMT) and occurrence of plaque formation. Flow velocities of bilateral middle cerebral arteries (MCAs), internal carotid arteries (ICAs) and basal artery (BA) were estimated through Transcranial Color Doppler (TCD). The results were compared with data from 33 patients who were free from radiation-induced temporal lobe necrosis after radiotherapy and 29 healthy individuals.<h4>Results</h4>Significant differences in IMT, occurrence of plaques of ICAs and flow velocities of both MCAs and ICAs were found between patients after radiotherapy and healthy individuals (p<0.05). IMT had positive correlation with post radiation interval (p = 0.049). Compared with results from patients without radiation-induced TLN, the mean IMT was significantly thicker in patients with TLN (p<0.001). Plaques were more common in patients with TLN than patients without TLN (p = 0.038). In addition, flow velocities of MCAs and ICAs in patients with TLN were much faster (p<0.001, p<0.001). Among patients with unilateral TLN, flow velocity of MCAs was significantly different between ipsilateral and contralateral sides to the lesion (p = 0.001).<h4>Conclusion</h4>Thickening of IMT, occurrence of plaque formation and hemodynamic abnormality are more common in patients after radiotherapy, especially in those with TLN, compared with healthy individuals.
format	article
author	Jianhong Ye Xiaoming Rong Yanqun Xiang Yigang Xing Yamei Tang
author_facet	Jianhong Ye Xiaoming Rong Yanqun Xiang Yigang Xing Yamei Tang
author_sort	Jianhong Ye
title	A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
title_short	A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
title_full	A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
title_fullStr	A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
title_full_unstemmed	A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
title_sort	study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/004d2a533905410a8d090cda9c1a8c63
work_keys_str_mv	AT jianhongye astudyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT xiaomingrong astudyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yanqunxiang astudyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yigangxing astudyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yameitang astudyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT jianhongye studyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT xiaomingrong studyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yanqunxiang studyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yigangxing studyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis AT yameitang studyofradiationinducedcerebralvascularinjuryinnasopharyngealcarcinomapatientswithradiationinducedtemporallobenecrosis
_version_	1718423831614324736

A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.

Ejemplares similares