Accurate imputation of human leukocyte antigens with CookHLA

Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenari...

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Autores principales:	Seungho Cook, Wanson Choi, Hyunjoon Lim, Yang Luo, Kunhee Kim, Xiaoming Jia, Soumya Raychaudhuri, Buhm Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/004f4796d69f4d56bd2fd5ed3d50b1b1
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spelling	oai:doaj.org-article:004f4796d69f4d56bd2fd5ed3d50b1b12021-12-02T13:34:29ZAccurate imputation of human leukocyte antigens with CookHLA10.1038/s41467-021-21541-52041-1723https://doaj.org/article/004f4796d69f4d56bd2fd5ed3d50b1b12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21541-5https://doaj.org/toc/2041-1723Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenarios.Seungho CookWanson ChoiHyunjoon LimYang LuoKunhee KimXiaoming JiaSoumya RaychaudhuriBuhm HanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seungho Cook Wanson Choi Hyunjoon Lim Yang Luo Kunhee Kim Xiaoming Jia Soumya Raychaudhuri Buhm Han Accurate imputation of human leukocyte antigens with CookHLA
description	Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenarios.
format	article
author	Seungho Cook Wanson Choi Hyunjoon Lim Yang Luo Kunhee Kim Xiaoming Jia Soumya Raychaudhuri Buhm Han
author_facet	Seungho Cook Wanson Choi Hyunjoon Lim Yang Luo Kunhee Kim Xiaoming Jia Soumya Raychaudhuri Buhm Han
author_sort	Seungho Cook
title	Accurate imputation of human leukocyte antigens with CookHLA
title_short	Accurate imputation of human leukocyte antigens with CookHLA
title_full	Accurate imputation of human leukocyte antigens with CookHLA
title_fullStr	Accurate imputation of human leukocyte antigens with CookHLA
title_full_unstemmed	Accurate imputation of human leukocyte antigens with CookHLA
title_sort	accurate imputation of human leukocyte antigens with cookhla
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/004f4796d69f4d56bd2fd5ed3d50b1b1
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Accurate imputation of human leukocyte antigens with CookHLA

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