TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.

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Detalles Bibliográficos
Autores principales:	Dong Hyun Kim, Joo Seok Han, Peter Ly, Qiaozhen Ye, Moira A. McMahon, Kyungjae Myung, Kevin D. Corbett, Don W. Cleveland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/004fb7b590f04129989b8ca5e5d620a7
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spelling	oai:doaj.org-article:004fb7b590f04129989b8ca5e5d620a72021-12-02T17:33:03ZTRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC10.1038/s41467-018-06774-12041-1723https://doaj.org/article/004fb7b590f04129989b8ca5e5d620a72018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06774-1https://doaj.org/toc/2041-1723The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.Dong Hyun KimJoo Seok HanPeter LyQiaozhen YeMoira A. McMahonKyungjae MyungKevin D. CorbettDon W. ClevelandNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dong Hyun Kim Joo Seok Han Peter Ly Qiaozhen Ye Moira A. McMahon Kyungjae Myung Kevin D. Corbett Don W. Cleveland TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
description	The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.
format	article
author	Dong Hyun Kim Joo Seok Han Peter Ly Qiaozhen Ye Moira A. McMahon Kyungjae Myung Kevin D. Corbett Don W. Cleveland
author_facet	Dong Hyun Kim Joo Seok Han Peter Ly Qiaozhen Ye Moira A. McMahon Kyungjae Myung Kevin D. Corbett Don W. Cleveland
author_sort	Dong Hyun Kim
title	TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
title_short	TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
title_full	TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
title_fullStr	TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
title_full_unstemmed	TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
title_sort	trip13 and apc15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced mcc
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/004fb7b590f04129989b8ca5e5d620a7
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TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

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