Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mateus H. Gouveia, Amy R. Bentley, Hampton Leonard, Karlijn A. C. Meeks, Kenneth Ekoru, Guanjie Chen, Michael A. Nalls, Eleanor M. Simonsick, Eduardo Tarazona-Santos, Maria Fernanda Lima-Costa, Adebowale Adeyemo, Daniel Shriner, Charles N. Rotimi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0053a1ca207d4af1a4a039816eafa93f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0053a1ca207d4af1a4a039816eafa93f
record_format	dspace
spelling	oai:doaj.org-article:0053a1ca207d4af1a4a039816eafa93f2021-12-02T14:03:44ZTrans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits10.1038/s41598-021-83450-32045-2322https://doaj.org/article/0053a1ca207d4af1a4a039816eafa93f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83450-3https://doaj.org/toc/2045-2322Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p = 7.3 × 10–9) with reported regulatory function. We observed a high correlation between the meta-analysis results for baseline and longitudinal average BP (rho = 0.48). BP trajectory results were more correlated with those of average BP (rho = 0.35) than baseline BP(rho = 0.18). Heritability estimates trended higher for longitudinal traits than for cross-sectional traits, providing evidence for different genetic architectures. Furthermore, the longitudinal data identified up to 20% more BP known associations than did cross-sectional data. Our analyses of longitudinal BP data in diverse ethnic groups identified novel BP loci associated with BP trajectory, indicating a need for further longitudinal GWAS on BP and other age-related traits.Mateus H. GouveiaAmy R. BentleyHampton LeonardKarlijn A. C. MeeksKenneth EkoruGuanjie ChenMichael A. NallsEleanor M. SimonsickEduardo Tarazona-SantosMaria Fernanda Lima-CostaAdebowale AdeyemoDaniel ShrinerCharles N. RotimiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mateus H. Gouveia Amy R. Bentley Hampton Leonard Karlijn A. C. Meeks Kenneth Ekoru Guanjie Chen Michael A. Nalls Eleanor M. Simonsick Eduardo Tarazona-Santos Maria Fernanda Lima-Costa Adebowale Adeyemo Daniel Shriner Charles N. Rotimi Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
description	Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p = 7.3 × 10–9) with reported regulatory function. We observed a high correlation between the meta-analysis results for baseline and longitudinal average BP (rho = 0.48). BP trajectory results were more correlated with those of average BP (rho = 0.35) than baseline BP(rho = 0.18). Heritability estimates trended higher for longitudinal traits than for cross-sectional traits, providing evidence for different genetic architectures. Furthermore, the longitudinal data identified up to 20% more BP known associations than did cross-sectional data. Our analyses of longitudinal BP data in diverse ethnic groups identified novel BP loci associated with BP trajectory, indicating a need for further longitudinal GWAS on BP and other age-related traits.
format	article
author	Mateus H. Gouveia Amy R. Bentley Hampton Leonard Karlijn A. C. Meeks Kenneth Ekoru Guanjie Chen Michael A. Nalls Eleanor M. Simonsick Eduardo Tarazona-Santos Maria Fernanda Lima-Costa Adebowale Adeyemo Daniel Shriner Charles N. Rotimi
author_facet	Mateus H. Gouveia Amy R. Bentley Hampton Leonard Karlijn A. C. Meeks Kenneth Ekoru Guanjie Chen Michael A. Nalls Eleanor M. Simonsick Eduardo Tarazona-Santos Maria Fernanda Lima-Costa Adebowale Adeyemo Daniel Shriner Charles N. Rotimi
author_sort	Mateus H. Gouveia
title	Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
title_short	Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
title_full	Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
title_fullStr	Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
title_full_unstemmed	Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
title_sort	trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0053a1ca207d4af1a4a039816eafa93f
work_keys_str_mv	AT mateushgouveia transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT amyrbentley transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT hamptonleonard transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT karlijnacmeeks transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT kennethekoru transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT guanjiechen transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT michaelanalls transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT eleanormsimonsick transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT eduardotarazonasantos transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT mariafernandalimacosta transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT adebowaleadeyemo transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT danielshriner transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits AT charlesnrotimi transethnicmetaanalysisidentifiesnewlociassociatedwithlongitudinalbloodpressuretraits
_version_	1718392061226385408

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

Ejemplares similares