Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.

<h4>Background</h4>Venom-induced acute kidney injury (AKI) is a frequent complication of Bothrops snakebite with relevant morbidity and mortality. The aim of this study was to assess the effects of Schizolobium parahyba (SP) extract, a natural medicine with presumed anti-Bothrops venom e...

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Autores principales:	Monique Silva Martines, Mirian M Mendes, Maria H M Shimizu, Veridiana Melo Rodrigues, Isac de Castro, Sebastião R Ferreira Filho, Denise M A C Malheiros, Luis Yu, Emmanuel A Burdmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0057c0f7bd204a8bbd186327a1d55c37
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spelling	oai:doaj.org-article:0057c0f7bd204a8bbd186327a1d55c372021-11-18T08:32:31ZEffects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.1932-620310.1371/journal.pone.0086828https://doaj.org/article/0057c0f7bd204a8bbd186327a1d55c372014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24551041/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Venom-induced acute kidney injury (AKI) is a frequent complication of Bothrops snakebite with relevant morbidity and mortality. The aim of this study was to assess the effects of Schizolobium parahyba (SP) extract, a natural medicine with presumed anti-Bothrops venom effects, in an experimental model of Bothrops jararaca venom (BV)-induced AKI.<h4>Methodology</h4>Groups of 8 to 10 rats received infusions of 0.9% saline (control, C), SP 2 mg/kg, BV 0.25 mg/kg and BV immediately followed by SP (treatment, T) in the doses already described. After the respective infusions, animals were assessed for their glomerular filtration rate (GFR, inulin clearance), renal blood flow (RBF, Doppler), blood pressure (BP, intra-arterial transducer), renal vascular resistance (RVR), urinary osmolality (UO, freezing point), urinary neutrophil gelatinase-associated lipocalin (NGAL, enzyme-linked immunosorbent assay [ELISA]), lactate dehydrogenase (LDH, kinetic method), hematocrit (Hct, microhematocrit), fibrinogen (Fi, Klauss modified) and blinded renal histology (acute tubular necrosis score).<h4>Principal findings</h4>BV caused significant decreases in GFR, RBF, UO, HcT and Fi; significant increases in RVR, NGAL and LDH; and acute tubular necrosis. SP did not prevent these changes; instead, it caused a significant decrease in GFR when used alone.<h4>Conclusion</h4>SP administered simultaneously with BV, in an approximate 10∶1 concentration, did not prevent BV-induced AKI, hemolysis and fibrinogen consumption. SP used alone caused a decrease in GFR.Monique Silva MartinesMirian M MendesMaria H M ShimizuVeridiana Melo RodriguesIsac de CastroSebastião R Ferreira FilhoDenise M A C MalheirosLuis YuEmmanuel A BurdmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e86828 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monique Silva Martines Mirian M Mendes Maria H M Shimizu Veridiana Melo Rodrigues Isac de Castro Sebastião R Ferreira Filho Denise M A C Malheiros Luis Yu Emmanuel A Burdmann Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
description	<h4>Background</h4>Venom-induced acute kidney injury (AKI) is a frequent complication of Bothrops snakebite with relevant morbidity and mortality. The aim of this study was to assess the effects of Schizolobium parahyba (SP) extract, a natural medicine with presumed anti-Bothrops venom effects, in an experimental model of Bothrops jararaca venom (BV)-induced AKI.<h4>Methodology</h4>Groups of 8 to 10 rats received infusions of 0.9% saline (control, C), SP 2 mg/kg, BV 0.25 mg/kg and BV immediately followed by SP (treatment, T) in the doses already described. After the respective infusions, animals were assessed for their glomerular filtration rate (GFR, inulin clearance), renal blood flow (RBF, Doppler), blood pressure (BP, intra-arterial transducer), renal vascular resistance (RVR), urinary osmolality (UO, freezing point), urinary neutrophil gelatinase-associated lipocalin (NGAL, enzyme-linked immunosorbent assay [ELISA]), lactate dehydrogenase (LDH, kinetic method), hematocrit (Hct, microhematocrit), fibrinogen (Fi, Klauss modified) and blinded renal histology (acute tubular necrosis score).<h4>Principal findings</h4>BV caused significant decreases in GFR, RBF, UO, HcT and Fi; significant increases in RVR, NGAL and LDH; and acute tubular necrosis. SP did not prevent these changes; instead, it caused a significant decrease in GFR when used alone.<h4>Conclusion</h4>SP administered simultaneously with BV, in an approximate 10∶1 concentration, did not prevent BV-induced AKI, hemolysis and fibrinogen consumption. SP used alone caused a decrease in GFR.
format	article
author	Monique Silva Martines Mirian M Mendes Maria H M Shimizu Veridiana Melo Rodrigues Isac de Castro Sebastião R Ferreira Filho Denise M A C Malheiros Luis Yu Emmanuel A Burdmann
author_facet	Monique Silva Martines Mirian M Mendes Maria H M Shimizu Veridiana Melo Rodrigues Isac de Castro Sebastião R Ferreira Filho Denise M A C Malheiros Luis Yu Emmanuel A Burdmann
author_sort	Monique Silva Martines
title	Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
title_short	Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
title_full	Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
title_fullStr	Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
title_full_unstemmed	Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.
title_sort	effects of schizolobium parahyba extract on experimental bothrops venom-induced acute kidney injury.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0057c0f7bd204a8bbd186327a1d55c37
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Effects of Schizolobium parahyba extract on experimental Bothrops venom-induced acute kidney injury.

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