ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS

Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search...

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Autores principales:	Diana M. MÁRQUEZ F., Alejandro MARTÍNEZ M.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2007
Materias:	Esponjas marinas Dyctioceratidae Ircinia epidioxiesteroles productos de degradación Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/005a76e229fe435296e72e510aa071ea
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spelling	oai:doaj.org-article:005a76e229fe435296e72e510aa071ea2021-12-02T04:33:23ZANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS0121-4004https://doaj.org/article/005a76e229fe435296e72e510aa071ea2007-01-01T00:00:00Zhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042007000100009&lng=en&tlng=enhttps://doaj.org/toc/0121-4004Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring Δ5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus.Diana M. MÁRQUEZ F.Alejandro MARTÍNEZ M.Universidad de AntioquiaarticleEsponjas marinasDyctioceratidaeIrciniaepidioxiesterolesproductos de degradaciónFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1, Pp 61-66 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Esponjas marinas Dyctioceratidae Ircinia epidioxiesteroles productos de degradación Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Esponjas marinas Dyctioceratidae Ircinia epidioxiesteroles productos de degradación Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M. ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
description	Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring Δ5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus.
format	article
author	Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M.
author_facet	Diana M. MÁRQUEZ F. Alejandro MARTÍNEZ M.
author_sort	Diana M. MÁRQUEZ F.
title	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
title_short	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
title_full	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
title_fullStr	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
title_full_unstemmed	ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS
title_sort	antileishmanial epidioxysterols from the colombian marine sponge ircinia campana are oxidation products from naturally occurring δ5,7 sterols
publisher	Universidad de Antioquia
publishDate	2007
url	https://doaj.org/article/005a76e229fe435296e72e510aa071ea
work_keys_str_mv	AT dianammarquezf antileishmanialepidioxysterolsfromthecolombianmarinespongeirciniacampanaareoxidationproductsfromnaturallyoccurringd57sterols AT alejandromartinezm antileishmanialepidioxysterolsfromthecolombianmarinespongeirciniacampanaareoxidationproductsfromnaturallyoccurringd57sterols
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ANTILEISHMANIAL EPIDIOXYSTEROLS FROM THE COLOMBIAN MARINE SPONGE Ircinia campana ARE OXIDATION PRODUCTS FROM NATURALLY OCCURRING Δ5,7 STEROLS

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