Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

Abstract Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanopa...

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Autores principales:	Abbas Moghanizadeh, Fakhreddin Ashrafizadeh, Jaleh Varshosaz, Antoine Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/005b3b902bd64170870eceb6f111572f
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spelling	oai:doaj.org-article:005b3b902bd64170870eceb6f111572f2021-12-02T17:19:17ZStudy the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles10.1038/s41598-021-97499-72045-2322https://doaj.org/article/005b3b902bd64170870eceb6f111572f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97499-7https://doaj.org/toc/2045-2322Abstract Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles carrying thrombolytic agents. In this research, Fe3O4@SiO2 nanoparticles carrying streptokinase were applied. The efficiency of thrombolysis and micro-CT-scan images are utilized to study the effect of different magnetic fields (0.1, 0.2, 0.3 and 0.5 T) on thrombolysis. The results confirm that increasing the static magnetic field intensity accelerated the thrombolysis. Increasing the intensity of the magnetic field from 0.1 to 0.3 T leads to an increase in clot dissolution rate from 55 to 89%, respectively. Moreover, micro-CT-scan images revealed that magnetic nanoparticles carrying a thrombolytic agent penetrated deeper into the mesh-like structure of clot as the magnetic field intensities increased, which could lead to further dissolution of the clot.Abbas MoghanizadehFakhreddin AshrafizadehJaleh VarshosazAntoine FerreiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Antoine Ferreira Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
description	Abstract Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles carrying thrombolytic agents. In this research, Fe3O4@SiO2 nanoparticles carrying streptokinase were applied. The efficiency of thrombolysis and micro-CT-scan images are utilized to study the effect of different magnetic fields (0.1, 0.2, 0.3 and 0.5 T) on thrombolysis. The results confirm that increasing the static magnetic field intensity accelerated the thrombolysis. Increasing the intensity of the magnetic field from 0.1 to 0.3 T leads to an increase in clot dissolution rate from 55 to 89%, respectively. Moreover, micro-CT-scan images revealed that magnetic nanoparticles carrying a thrombolytic agent penetrated deeper into the mesh-like structure of clot as the magnetic field intensities increased, which could lead to further dissolution of the clot.
format	article
author	Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Antoine Ferreira
author_facet	Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Antoine Ferreira
author_sort	Abbas Moghanizadeh
title	Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
title_short	Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
title_full	Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
title_fullStr	Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
title_full_unstemmed	Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
title_sort	study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/005b3b902bd64170870eceb6f111572f
work_keys_str_mv	AT abbasmoghanizadeh studytheeffectofstaticmagneticfieldintensityondrugdeliverybymagneticnanoparticles AT fakhreddinashrafizadeh studytheeffectofstaticmagneticfieldintensityondrugdeliverybymagneticnanoparticles AT jalehvarshosaz studytheeffectofstaticmagneticfieldintensityondrugdeliverybymagneticnanoparticles AT antoineferreira studytheeffectofstaticmagneticfieldintensityondrugdeliverybymagneticnanoparticles
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Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

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