Activation of STING requires palmitoylation at the Golgi

STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.

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Autores principales:	Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N. Barber, Hiroyuki Arai, Tomohiko Taguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/005c19e978c34d6c8e60b4bff03ce1f4
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spelling	oai:doaj.org-article:005c19e978c34d6c8e60b4bff03ce1f42021-12-02T16:50:14ZActivation of STING requires palmitoylation at the Golgi10.1038/ncomms119322041-1723https://doaj.org/article/005c19e978c34d6c8e60b4bff03ce1f42016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11932https://doaj.org/toc/2041-1723STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.Kojiro MukaiHiroyasu KonnoTatsuya AkibaTakefumi UemuraSatoshi WaguriToshihide KobayashiGlen N. BarberHiroyuki AraiTomohiko TaguchiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kojiro Mukai Hiroyasu Konno Tatsuya Akiba Takefumi Uemura Satoshi Waguri Toshihide Kobayashi Glen N. Barber Hiroyuki Arai Tomohiko Taguchi Activation of STING requires palmitoylation at the Golgi
description	STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.
format	article
author	Kojiro Mukai Hiroyasu Konno Tatsuya Akiba Takefumi Uemura Satoshi Waguri Toshihide Kobayashi Glen N. Barber Hiroyuki Arai Tomohiko Taguchi
author_facet	Kojiro Mukai Hiroyasu Konno Tatsuya Akiba Takefumi Uemura Satoshi Waguri Toshihide Kobayashi Glen N. Barber Hiroyuki Arai Tomohiko Taguchi
author_sort	Kojiro Mukai
title	Activation of STING requires palmitoylation at the Golgi
title_short	Activation of STING requires palmitoylation at the Golgi
title_full	Activation of STING requires palmitoylation at the Golgi
title_fullStr	Activation of STING requires palmitoylation at the Golgi
title_full_unstemmed	Activation of STING requires palmitoylation at the Golgi
title_sort	activation of sting requires palmitoylation at the golgi
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/005c19e978c34d6c8e60b4bff03ce1f4
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Activation of STING requires palmitoylation at the Golgi

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