BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T...

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Autores principales: Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:005ce01fdf404b9e94d9cc3e5ef8afe12021-11-18T07:37:10ZBCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals1932-6203https://doaj.org/article/005ce01fdf404b9e94d9cc3e5ef8afe12021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580239/?tool=EBIhttps://doaj.org/toc/1932-6203BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T cell subsets and common gamma c (γc) cytokines in a group of healthy elderly individuals (age 60–80 years) at one month post vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrate that BCG vaccination induced enhanced frequencies of central (p<0.0001) and effector memory (p<0.0001) CD4+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001), stem cell memory (p = 0.0001) CD4+ T cells and regulatory T cells. In addition, BCG vaccination induced enhanced frequencies of central (p = 0.0008), effector (p<0.0001) and terminal effector memory (p<0.0001) CD8+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001) and stem cell memory (p = 0.0034) CD8+T cells. BCG vaccination also induced enhanced plasma levels of IL-7 (p<0.0001) and IL-15 (p = 0.0020) but diminished levels of IL-2 (p = 0.0033) and IL-21 (p = 0.0020). Thus, BCG vaccination was associated with enhanced memory T cell subsets as well as memory enhancing γc cytokines in elderly individuals, suggesting its ability to induce non-specific adaptive immune responses.Nathella Pavan KumarChandrasekaran PadmapriyadarsiniAnuradha RajamanickamPerumal Kannabiran BhavaniArul NancyBharathi JayadeepaNandhini SelvarajDinesh AsokanRachel Mariam RenjiVijayalakshmi VenkataramaniSrikanth TripathySubash BabuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nathella Pavan Kumar
Chandrasekaran Padmapriyadarsini
Anuradha Rajamanickam
Perumal Kannabiran Bhavani
Arul Nancy
Bharathi Jayadeepa
Nandhini Selvaraj
Dinesh Asokan
Rachel Mariam Renji
Vijayalakshmi Venkataramani
Srikanth Tripathy
Subash Babu
BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
description BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T cell subsets and common gamma c (γc) cytokines in a group of healthy elderly individuals (age 60–80 years) at one month post vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrate that BCG vaccination induced enhanced frequencies of central (p<0.0001) and effector memory (p<0.0001) CD4+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001), stem cell memory (p = 0.0001) CD4+ T cells and regulatory T cells. In addition, BCG vaccination induced enhanced frequencies of central (p = 0.0008), effector (p<0.0001) and terminal effector memory (p<0.0001) CD8+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001) and stem cell memory (p = 0.0034) CD8+T cells. BCG vaccination also induced enhanced plasma levels of IL-7 (p<0.0001) and IL-15 (p = 0.0020) but diminished levels of IL-2 (p = 0.0033) and IL-21 (p = 0.0020). Thus, BCG vaccination was associated with enhanced memory T cell subsets as well as memory enhancing γc cytokines in elderly individuals, suggesting its ability to induce non-specific adaptive immune responses.
format article
author Nathella Pavan Kumar
Chandrasekaran Padmapriyadarsini
Anuradha Rajamanickam
Perumal Kannabiran Bhavani
Arul Nancy
Bharathi Jayadeepa
Nandhini Selvaraj
Dinesh Asokan
Rachel Mariam Renji
Vijayalakshmi Venkataramani
Srikanth Tripathy
Subash Babu
author_facet Nathella Pavan Kumar
Chandrasekaran Padmapriyadarsini
Anuradha Rajamanickam
Perumal Kannabiran Bhavani
Arul Nancy
Bharathi Jayadeepa
Nandhini Selvaraj
Dinesh Asokan
Rachel Mariam Renji
Vijayalakshmi Venkataramani
Srikanth Tripathy
Subash Babu
author_sort Nathella Pavan Kumar
title BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
title_short BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
title_full BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
title_fullStr BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
title_full_unstemmed BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals
title_sort bcg vaccination induces enhanced frequencies of memory t cells and altered plasma levels of common γc cytokines in elderly individuals
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/005ce01fdf404b9e94d9cc3e5ef8afe1
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