Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RI...
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Nature Portfolio
2016
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oai:doaj.org-article:005dc6f1a7ee4f02bb86db514a26a4622021-12-02T16:57:02ZSyndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD10.1038/ncomms118482041-1723https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a4622016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11848https://doaj.org/toc/2041-1723Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination.Wei LinJing ZhangHaiyan LinZexing LiXiaofeng SunDi XinMeng YangLiwei SunLin LiHongmei WangDahua ChenQinmiao SunNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q Wei Lin Jing Zhang Haiyan Lin Zexing Li Xiaofeng Sun Di Xin Meng Yang Liwei Sun Lin Li Hongmei Wang Dahua Chen Qinmiao Sun Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
description |
Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination. |
format |
article |
author |
Wei Lin Jing Zhang Haiyan Lin Zexing Li Xiaofeng Sun Di Xin Meng Yang Liwei Sun Lin Li Hongmei Wang Dahua Chen Qinmiao Sun |
author_facet |
Wei Lin Jing Zhang Haiyan Lin Zexing Li Xiaofeng Sun Di Xin Meng Yang Liwei Sun Lin Li Hongmei Wang Dahua Chen Qinmiao Sun |
author_sort |
Wei Lin |
title |
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
title_short |
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
title_full |
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
title_fullStr |
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
title_full_unstemmed |
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD |
title_sort |
syndecan-4 negatively regulates antiviral signalling by mediating rig-i deubiquitination via cyld |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a462 |
work_keys_str_mv |
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