Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RI...

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Main Authors: Wei Lin, Jing Zhang, Haiyan Lin, Zexing Li, Xiaofeng Sun, Di Xin, Meng Yang, Liwei Sun, Lin Li, Hongmei Wang, Dahua Chen, Qinmiao Sun
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a462
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spelling oai:doaj.org-article:005dc6f1a7ee4f02bb86db514a26a4622021-12-02T16:57:02ZSyndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD10.1038/ncomms118482041-1723https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a4622016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11848https://doaj.org/toc/2041-1723Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination.Wei LinJing ZhangHaiyan LinZexing LiXiaofeng SunDi XinMeng YangLiwei SunLin LiHongmei WangDahua ChenQinmiao SunNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wei Lin
Jing Zhang
Haiyan Lin
Zexing Li
Xiaofeng Sun
Di Xin
Meng Yang
Liwei Sun
Lin Li
Hongmei Wang
Dahua Chen
Qinmiao Sun
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
description Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination.
format article
author Wei Lin
Jing Zhang
Haiyan Lin
Zexing Li
Xiaofeng Sun
Di Xin
Meng Yang
Liwei Sun
Lin Li
Hongmei Wang
Dahua Chen
Qinmiao Sun
author_facet Wei Lin
Jing Zhang
Haiyan Lin
Zexing Li
Xiaofeng Sun
Di Xin
Meng Yang
Liwei Sun
Lin Li
Hongmei Wang
Dahua Chen
Qinmiao Sun
author_sort Wei Lin
title Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
title_short Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
title_full Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
title_fullStr Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
title_full_unstemmed Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
title_sort syndecan-4 negatively regulates antiviral signalling by mediating rig-i deubiquitination via cyld
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a462
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