Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival

BackgroundDue to the fact that the definition of gastric signet ring cell cancer (GSRC) was still controversial in the past decades, the prognosis affected by the proportion of signet ring cells within gastric cancer is uncertain. This study compared the clinicopathological features and prognosis of...

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Autores principales:	Yang Li, Yuxin Zhong, Quan Xu, Zhikai Zhu, Yantao Tian
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gastric cancer signet ring cell cancer survival prognosis treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/005e7d6ba8174fd98f1fec34e42b9b15
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spelling	oai:doaj.org-article:005e7d6ba8174fd98f1fec34e42b9b152021-11-09T05:16:07ZPrognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival2234-943X10.3389/fonc.2021.713587https://doaj.org/article/005e7d6ba8174fd98f1fec34e42b9b152021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.713587/fullhttps://doaj.org/toc/2234-943XBackgroundDue to the fact that the definition of gastric signet ring cell cancer (GSRC) was still controversial in the past decades, the prognosis affected by the proportion of signet ring cells within gastric cancer is uncertain. This study compared the clinicopathological features and prognosis of GSRC with the various proportions of signet ring cells.MethodsWe collected GSRC cases without metastasis who underwent curative (R0) resection between 2011 and 2018. Individuals who were in the low-proportion signet ring cell group (LSRC, <50%) were matched to those who were in the high-proportion signet ring cell group (HSRC, >50%) through propensity score matching (1:1). We used Cox proportional hazard regression to calculate the adjusted hazard ratios (HR) and 95% confidence intervals (CI) and explored interactions with gender and stage.ResultsWe had 1:1 matched individuals including 231 cases from the LSRC group and 231 cases from the HSRC group. Patients with HSRC had a significantly higher overall survival rate in the multivariable model (aHR = 0.56, 95%CI = 0.38, 0.84) compared with those with LSRC. The association of HSRC appeared to be more substantial among individuals at early stage and N0 stage (p-interaction < 0.01).ConclusionsThis study confirms that GSRC with different proportions of signet ring cells could affect the survival of the patient. Further clinical studies should be developed in the future to provide an appropriate treatment strategy for GSRC.Yang LiYuxin ZhongQuan XuZhikai ZhuYantao TianFrontiers Media S.A.articlegastric cancersignet ring cellcancer survivalprognosistreatmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer signet ring cell cancer survival prognosis treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	gastric cancer signet ring cell cancer survival prognosis treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang Li Yuxin Zhong Quan Xu Zhikai Zhu Yantao Tian Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
description	BackgroundDue to the fact that the definition of gastric signet ring cell cancer (GSRC) was still controversial in the past decades, the prognosis affected by the proportion of signet ring cells within gastric cancer is uncertain. This study compared the clinicopathological features and prognosis of GSRC with the various proportions of signet ring cells.MethodsWe collected GSRC cases without metastasis who underwent curative (R0) resection between 2011 and 2018. Individuals who were in the low-proportion signet ring cell group (LSRC, <50%) were matched to those who were in the high-proportion signet ring cell group (HSRC, >50%) through propensity score matching (1:1). We used Cox proportional hazard regression to calculate the adjusted hazard ratios (HR) and 95% confidence intervals (CI) and explored interactions with gender and stage.ResultsWe had 1:1 matched individuals including 231 cases from the LSRC group and 231 cases from the HSRC group. Patients with HSRC had a significantly higher overall survival rate in the multivariable model (aHR = 0.56, 95%CI = 0.38, 0.84) compared with those with LSRC. The association of HSRC appeared to be more substantial among individuals at early stage and N0 stage (p-interaction < 0.01).ConclusionsThis study confirms that GSRC with different proportions of signet ring cells could affect the survival of the patient. Further clinical studies should be developed in the future to provide an appropriate treatment strategy for GSRC.
format	article
author	Yang Li Yuxin Zhong Quan Xu Zhikai Zhu Yantao Tian
author_facet	Yang Li Yuxin Zhong Quan Xu Zhikai Zhu Yantao Tian
author_sort	Yang Li
title	Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
title_short	Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
title_full	Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
title_fullStr	Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
title_full_unstemmed	Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival
title_sort	prognostic significance of signet ring cells in gastric cancer: the higher proportion, the better survival
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/005e7d6ba8174fd98f1fec34e42b9b15
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Prognostic Significance of Signet Ring Cells in Gastric Cancer: The Higher Proportion, The Better Survival

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