Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide

Rania S Abdel-Rashid,1 Doaa A Helal,2 Mahmoud M Omar,3,4 Amani M El Sisi51Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt; 2Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt; 3Pharmaceutics a...

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Autores principales:	Abdel-Rashid RS, Helal DA, Omar MM, El Sisi AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Nanogels Acetazoleamide IOP nanovesicles edge activators ocular delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0065829dd3e643119f000aceb5a19ae0
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spelling	oai:doaj.org-article:0065829dd3e643119f000aceb5a19ae02021-12-02T07:37:10ZNanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide1178-2013https://doaj.org/article/0065829dd3e643119f000aceb5a19ae02019-04-01T00:00:00Zhttps://www.dovepress.com/nanogel-loaded-with-surfactant-based-nanovesicles-for-enhanced-ocular--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rania S Abdel-Rashid,1 Doaa A Helal,2 Mahmoud M Omar,3,4 Amani M El Sisi51Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt; 2Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt; 3Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Deraya University, El-Minia, Egypt; 4Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt; 5Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Banī Suwayf, EgyptObjective: Intraocular pressure has always been a great challenge for topical ophthalmic drugs. The study aimed to develop ocular surfactant based nanovesicles (NVs) carried in mucoadhesive nanogel providing efficient topical delivery of acetazolamide (ACZ).Methods: For the sake of optimizing formulation parameters, the effect of the type of edge activator and its ratio to sorbitan monostearate (Span 60) on the mean particle size, entrapment efficiency (%EE), and zeta potential (ZP) of produced NVs was investigated.Results: The selected formulation composed of Span 60:sodium deoxycholate with ratio 80:20 showed an average diameter of 202.90 nm, %EE of 90.2%, and ZP of −38.1 mV with a spherical and smooth surface. The ACZ loaded nanovesicles (ACZ-NVs) were embedded in different concentrations of Chitosan–sodium tripolyphosphate (CS-TPP) nanogels. The nanogel prepared using 1.5% CS showed the most promising viscosity, adhesion time, and rheological behavior (118,246 cP, 290 min, and thixotropic behavior, respectively). The in vitro release of ACZ showed a controlled release profile after incorporation in nanogels. The in vivo irritation test showed minimal irritation for the nanogel formulation compared to ACZ topical suspension. The effect of intraocular pressure lowering was significantly prolonged using ACZ-NV nanogels compared to ACZ oral tablets. Histopathological examination emphasized the healing power of CS on retinal atrophy.Conclusion: The research work indicated a promising potential for successful topical delivery of ACZ.Keywords: nanogels, acetazoleamide, intraocular pressure, nanovesicles, edge activators, ocular deliveryAbdel-Rashid RSHelal DAOmar MMEl Sisi AMDove Medical PressarticleNanogelsAcetazoleamideIOPnanovesiclesedge activatorsocular deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2973-2983 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanogels Acetazoleamide IOP nanovesicles edge activators ocular delivery Medicine (General) R5-920
spellingShingle	Nanogels Acetazoleamide IOP nanovesicles edge activators ocular delivery Medicine (General) R5-920 Abdel-Rashid RS Helal DA Omar MM El Sisi AM Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
description	Rania S Abdel-Rashid,1 Doaa A Helal,2 Mahmoud M Omar,3,4 Amani M El Sisi51Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt; 2Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt; 3Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Deraya University, El-Minia, Egypt; 4Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt; 5Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Banī Suwayf, EgyptObjective: Intraocular pressure has always been a great challenge for topical ophthalmic drugs. The study aimed to develop ocular surfactant based nanovesicles (NVs) carried in mucoadhesive nanogel providing efficient topical delivery of acetazolamide (ACZ).Methods: For the sake of optimizing formulation parameters, the effect of the type of edge activator and its ratio to sorbitan monostearate (Span 60) on the mean particle size, entrapment efficiency (%EE), and zeta potential (ZP) of produced NVs was investigated.Results: The selected formulation composed of Span 60:sodium deoxycholate with ratio 80:20 showed an average diameter of 202.90 nm, %EE of 90.2%, and ZP of −38.1 mV with a spherical and smooth surface. The ACZ loaded nanovesicles (ACZ-NVs) were embedded in different concentrations of Chitosan–sodium tripolyphosphate (CS-TPP) nanogels. The nanogel prepared using 1.5% CS showed the most promising viscosity, adhesion time, and rheological behavior (118,246 cP, 290 min, and thixotropic behavior, respectively). The in vitro release of ACZ showed a controlled release profile after incorporation in nanogels. The in vivo irritation test showed minimal irritation for the nanogel formulation compared to ACZ topical suspension. The effect of intraocular pressure lowering was significantly prolonged using ACZ-NV nanogels compared to ACZ oral tablets. Histopathological examination emphasized the healing power of CS on retinal atrophy.Conclusion: The research work indicated a promising potential for successful topical delivery of ACZ.Keywords: nanogels, acetazoleamide, intraocular pressure, nanovesicles, edge activators, ocular delivery
format	article
author	Abdel-Rashid RS Helal DA Omar MM El Sisi AM
author_facet	Abdel-Rashid RS Helal DA Omar MM El Sisi AM
author_sort	Abdel-Rashid RS
title	Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
title_short	Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
title_full	Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
title_fullStr	Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
title_full_unstemmed	Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
title_sort	nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0065829dd3e643119f000aceb5a19ae0
work_keys_str_mv	AT abdelrashidrs nanogelloadedwithsurfactantbasednanovesiclesforenhancedoculardeliveryofacetazolamide AT helalda nanogelloadedwithsurfactantbasednanovesiclesforenhancedoculardeliveryofacetazolamide AT omarmm nanogelloadedwithsurfactantbasednanovesiclesforenhancedoculardeliveryofacetazolamide AT elsisiam nanogelloadedwithsurfactantbasednanovesiclesforenhancedoculardeliveryofacetazolamide
_version_	1718399258577600512

Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide

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