Arylmethylamino steroids as antiparasitic agents

Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide mechanism, and has activity against Schistosoma ma...

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Autores principales:	Reimar Krieg, Esther Jortzik, Alice-Anne Goetz, Stéphanie Blandin, Sergio Wittlin, Mourad Elhabiri, Mahsa Rahbari, Selbi Nuryyeva, Kerstin Voigt, Hans-Martin Dahse, Axel Brakhage, Svenja Beckmann, Thomas Quack, Christoph G. Grevelding, Anthony B. Pinkerton, Bruno Schönecker, Jeremy Burrows, Elisabeth Davioud-Charvet, Stefan Rahlfs, Katja Becker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00677fe185ed4193bb6f7cdfdfcd60a9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:00677fe185ed4193bb6f7cdfdfcd60a92021-12-02T17:06:03ZArylmethylamino steroids as antiparasitic agents10.1038/ncomms144782041-1723https://doaj.org/article/00677fe185ed4193bb6f7cdfdfcd60a92017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14478https://doaj.org/toc/2041-1723Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide mechanism, and has activity against Schistosoma mansoni.Reimar KriegEsther JortzikAlice-Anne GoetzStéphanie BlandinSergio WittlinMourad ElhabiriMahsa RahbariSelbi NuryyevaKerstin VoigtHans-Martin DahseAxel BrakhageSvenja BeckmannThomas QuackChristoph G. GreveldingAnthony B. PinkertonBruno SchöneckerJeremy BurrowsElisabeth Davioud-CharvetStefan RahlfsKatja BeckerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reimar Krieg Esther Jortzik Alice-Anne Goetz Stéphanie Blandin Sergio Wittlin Mourad Elhabiri Mahsa Rahbari Selbi Nuryyeva Kerstin Voigt Hans-Martin Dahse Axel Brakhage Svenja Beckmann Thomas Quack Christoph G. Grevelding Anthony B. Pinkerton Bruno Schönecker Jeremy Burrows Elisabeth Davioud-Charvet Stefan Rahlfs Katja Becker Arylmethylamino steroids as antiparasitic agents
description	Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide mechanism, and has activity against Schistosoma mansoni.
format	article
author	Reimar Krieg Esther Jortzik Alice-Anne Goetz Stéphanie Blandin Sergio Wittlin Mourad Elhabiri Mahsa Rahbari Selbi Nuryyeva Kerstin Voigt Hans-Martin Dahse Axel Brakhage Svenja Beckmann Thomas Quack Christoph G. Grevelding Anthony B. Pinkerton Bruno Schönecker Jeremy Burrows Elisabeth Davioud-Charvet Stefan Rahlfs Katja Becker
author_facet	Reimar Krieg Esther Jortzik Alice-Anne Goetz Stéphanie Blandin Sergio Wittlin Mourad Elhabiri Mahsa Rahbari Selbi Nuryyeva Kerstin Voigt Hans-Martin Dahse Axel Brakhage Svenja Beckmann Thomas Quack Christoph G. Grevelding Anthony B. Pinkerton Bruno Schönecker Jeremy Burrows Elisabeth Davioud-Charvet Stefan Rahlfs Katja Becker
author_sort	Reimar Krieg
title	Arylmethylamino steroids as antiparasitic agents
title_short	Arylmethylamino steroids as antiparasitic agents
title_full	Arylmethylamino steroids as antiparasitic agents
title_fullStr	Arylmethylamino steroids as antiparasitic agents
title_full_unstemmed	Arylmethylamino steroids as antiparasitic agents
title_sort	arylmethylamino steroids as antiparasitic agents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00677fe185ed4193bb6f7cdfdfcd60a9
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Arylmethylamino steroids as antiparasitic agents

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