Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment

Abstract We used 3D printed-breast surgical guides (3DP-BSG) to designate the original tumor area from the pre-treatment magnetic resonance imaging (MRI) during breast-conserving surgery (BCS) in breast cancer patients who received neoadjuvant systemic therapy (NST). Targeting the original tumor are...

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Autores principales:	Han Shin Lee, Hee Jeong Kim, Il Yong Chung, Jisun Kim, Sae Byul Lee, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Hak Hee Kim, Joon Beom Seo, Jin Hee Ahn, Gyungyub Gong, Sangwook Lee, Namkug Kim, Beom Seok Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/006a24e6507e4bce890c64562c24a7e1
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spelling	oai:doaj.org-article:006a24e6507e4bce890c64562c24a7e12021-12-02T13:30:22ZUsefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment10.1038/s41598-021-83114-22045-2322https://doaj.org/article/006a24e6507e4bce890c64562c24a7e12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83114-2https://doaj.org/toc/2045-2322Abstract We used 3D printed-breast surgical guides (3DP-BSG) to designate the original tumor area from the pre-treatment magnetic resonance imaging (MRI) during breast-conserving surgery (BCS) in breast cancer patients who received neoadjuvant systemic therapy (NST). Targeting the original tumor area in such patients using conventional localization techniques is difficult. For precise BCS, a method that marks the tumor area found on MRI directly to the breast is needed. In this prospective study, patients were enrolled for BCS after receiving NST. Partial resection was performed using a prone/supine MRI-based 3DP-BSG. Frozen biopsies were analyzed to confirm clear tumor margins. The tumor characteristics, pathologic results, resection margins, and the distance between the tumor and margin were analyzed. Thirty-nine patients were enrolled with 3DP-BSG for BCS. The median nearest distance between the tumor and the resection margin was 3.9 cm (range 1.2–7.8 cm). Frozen sections showed positive margins in 4/39 (10.3%) patients. Three had invasive cancers, and one had carcinoma in situ; all underwent additional resection. Final pathology revealed clear margins. After 3-year surveillance, 3/39 patients had recurrent breast cancer. With 3DP-BSG for BCS in breast cancer patients receiving NST, the original tumor area can be identified and marked directly on the breast, which is useful for surgery. Trial Registration: Clinical Research Information Service (CRIS) Identifier Number: KCT0002272. First registration number and date: No. 1 (27/04/2016).Han Shin LeeHee Jeong KimIl Yong ChungJisun KimSae Byul LeeJong Won LeeByung Ho SonSei Hyun AhnHak Hee KimJoon Beom SeoJin Hee AhnGyungyub GongSangwook LeeNamkug KimBeom Seok KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Han Shin Lee Hee Jeong Kim Il Yong Chung Jisun Kim Sae Byul Lee Jong Won Lee Byung Ho Son Sei Hyun Ahn Hak Hee Kim Joon Beom Seo Jin Hee Ahn Gyungyub Gong Sangwook Lee Namkug Kim Beom Seok Ko Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
description	Abstract We used 3D printed-breast surgical guides (3DP-BSG) to designate the original tumor area from the pre-treatment magnetic resonance imaging (MRI) during breast-conserving surgery (BCS) in breast cancer patients who received neoadjuvant systemic therapy (NST). Targeting the original tumor area in such patients using conventional localization techniques is difficult. For precise BCS, a method that marks the tumor area found on MRI directly to the breast is needed. In this prospective study, patients were enrolled for BCS after receiving NST. Partial resection was performed using a prone/supine MRI-based 3DP-BSG. Frozen biopsies were analyzed to confirm clear tumor margins. The tumor characteristics, pathologic results, resection margins, and the distance between the tumor and margin were analyzed. Thirty-nine patients were enrolled with 3DP-BSG for BCS. The median nearest distance between the tumor and the resection margin was 3.9 cm (range 1.2–7.8 cm). Frozen sections showed positive margins in 4/39 (10.3%) patients. Three had invasive cancers, and one had carcinoma in situ; all underwent additional resection. Final pathology revealed clear margins. After 3-year surveillance, 3/39 patients had recurrent breast cancer. With 3DP-BSG for BCS in breast cancer patients receiving NST, the original tumor area can be identified and marked directly on the breast, which is useful for surgery. Trial Registration: Clinical Research Information Service (CRIS) Identifier Number: KCT0002272. First registration number and date: No. 1 (27/04/2016).
format	article
author	Han Shin Lee Hee Jeong Kim Il Yong Chung Jisun Kim Sae Byul Lee Jong Won Lee Byung Ho Son Sei Hyun Ahn Hak Hee Kim Joon Beom Seo Jin Hee Ahn Gyungyub Gong Sangwook Lee Namkug Kim Beom Seok Ko
author_facet	Han Shin Lee Hee Jeong Kim Il Yong Chung Jisun Kim Sae Byul Lee Jong Won Lee Byung Ho Son Sei Hyun Ahn Hak Hee Kim Joon Beom Seo Jin Hee Ahn Gyungyub Gong Sangwook Lee Namkug Kim Beom Seok Ko
author_sort	Han Shin Lee
title	Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
title_short	Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
title_full	Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
title_fullStr	Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
title_full_unstemmed	Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
title_sort	usefulness of 3d-surgical guides in breast conserving surgery after neoadjuvant treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/006a24e6507e4bce890c64562c24a7e1
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Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment

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