INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS

Abstract. Pathogenesis of reactive arthritis (ReA) is not clear yet. Several trials suggest that increased production of proinflammatory cytokines is responsible for development of arthritis in ReA, while other studies report that Th1 cytokine response in ReA is impaired in favor of Th2 response. Th...

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Autores principales:	T. V. Gaponova, A. M. Lila, T. G. Shemerovskaya, G. A. Zakharova, T. N. Maslyaeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	reactive arthritis infection cytokines il-1β il-4 il-6 tnfα ifnγ il-1ra Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/006ad846aca148509bc734ebb12f0ab9
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spelling	oai:doaj.org-article:006ad846aca148509bc734ebb12f0ab92021-11-18T08:03:38ZINVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS1563-06252313-741X10.15789/1563-0625-2008-2-3-167-172https://doaj.org/article/006ad846aca148509bc734ebb12f0ab92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/121https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Pathogenesis of reactive arthritis (ReA) is not clear yet. Several trials suggest that increased production of proinflammatory cytokines is responsible for development of arthritis in ReA, while other studies report that Th1 cytokine response in ReA is impaired in favor of Th2 response. The aim of our study was to investigate serum levels of cytokines IL-1β, IL-4, IL-6, TNFα, IFNγ and IL-1Ra in the patients with ReA of different etiology, as compared with infection-related arthritis. The results of our study had demonstrated that serum levels of IL-1β and TNFα in the patients with ReA were significantly higher, whereas IL-1Ra, IL-4, IL-6 proved to be significantly lower than in healthy controls. Serum levels of IL-6 were significantly higher in patients with chronic ReA, as compared to the cases of acute and recurrent ReA. No significant differences in cytokine profiles were found between the patients with ReA, and the persons with infection-related arthritis. The data obtained are, generally, suggestive for proinflammatory Th1 cytokine profile in ReA patients studied, this confirming the mostly assumed pathogenetic hypothesis for reactive arthritis where an underlying cytokine imbalance is suggested. (Med. Immunol., 2008, vol. 10, N 2-3, pp 167-172).T. V. GaponovaA. M. LilaT. G. ShemerovskayaG. A. ZakharovaT. N. MaslyaevaSPb RAACIarticlereactive arthritisinfectioncytokinesil-1βil-4il-6tnfαifnγil-1raImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 167-172 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	reactive arthritis infection cytokines il-1β il-4 il-6 tnfα ifnγ il-1ra Immunologic diseases. Allergy RC581-607
spellingShingle	reactive arthritis infection cytokines il-1β il-4 il-6 tnfα ifnγ il-1ra Immunologic diseases. Allergy RC581-607 T. V. Gaponova A. M. Lila T. G. Shemerovskaya G. A. Zakharova T. N. Maslyaeva INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
description	Abstract. Pathogenesis of reactive arthritis (ReA) is not clear yet. Several trials suggest that increased production of proinflammatory cytokines is responsible for development of arthritis in ReA, while other studies report that Th1 cytokine response in ReA is impaired in favor of Th2 response. The aim of our study was to investigate serum levels of cytokines IL-1β, IL-4, IL-6, TNFα, IFNγ and IL-1Ra in the patients with ReA of different etiology, as compared with infection-related arthritis. The results of our study had demonstrated that serum levels of IL-1β and TNFα in the patients with ReA were significantly higher, whereas IL-1Ra, IL-4, IL-6 proved to be significantly lower than in healthy controls. Serum levels of IL-6 were significantly higher in patients with chronic ReA, as compared to the cases of acute and recurrent ReA. No significant differences in cytokine profiles were found between the patients with ReA, and the persons with infection-related arthritis. The data obtained are, generally, suggestive for proinflammatory Th1 cytokine profile in ReA patients studied, this confirming the mostly assumed pathogenetic hypothesis for reactive arthritis where an underlying cytokine imbalance is suggested. (Med. Immunol., 2008, vol. 10, N 2-3, pp 167-172).
format	article
author	T. V. Gaponova A. M. Lila T. G. Shemerovskaya G. A. Zakharova T. N. Maslyaeva
author_facet	T. V. Gaponova A. M. Lila T. G. Shemerovskaya G. A. Zakharova T. N. Maslyaeva
author_sort	T. V. Gaponova
title	INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
title_short	INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
title_full	INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
title_fullStr	INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
title_full_unstemmed	INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
title_sort	investigation of cytokine profile in patients with reactive arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/006ad846aca148509bc734ebb12f0ab9
work_keys_str_mv	AT tvgaponova investigationofcytokineprofileinpatientswithreactivearthritis AT amlila investigationofcytokineprofileinpatientswithreactivearthritis AT tgshemerovskaya investigationofcytokineprofileinpatientswithreactivearthritis AT gazakharova investigationofcytokineprofileinpatientswithreactivearthritis AT tnmaslyaeva investigationofcytokineprofileinpatientswithreactivearthritis
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INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS

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