Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

Germline genes are repressed by DNA methylation and histone marks. Here, the authors show that specific germline genes hypomethylated pre-implantation are enriched for PRC1.6, H2AK119ub1 and H3K9me3, which coordinately repress their expression.

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Autores principales:	Kentaro Mochizuki, Jafar Sharif, Kenjiro Shirane, Kousuke Uranishi, Aaron B. Bogutz, Sanne M. Janssen, Ayumu Suzuki, Akihiko Okuda, Haruhiko Koseki, Matthew C. Lorincz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/006b6218cf214219b0b8f0d42574bd86
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spelling	oai:doaj.org-article:006b6218cf214219b0b8f0d42574bd862021-12-05T12:21:56ZRepression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing10.1038/s41467-021-27345-x2041-1723https://doaj.org/article/006b6218cf214219b0b8f0d42574bd862021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27345-xhttps://doaj.org/toc/2041-1723Germline genes are repressed by DNA methylation and histone marks. Here, the authors show that specific germline genes hypomethylated pre-implantation are enriched for PRC1.6, H2AK119ub1 and H3K9me3, which coordinately repress their expression.Kentaro MochizukiJafar SharifKenjiro ShiraneKousuke UranishiAaron B. BogutzSanne M. JanssenAyumu SuzukiAkihiko OkudaHaruhiko KosekiMatthew C. LorinczNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kentaro Mochizuki Jafar Sharif Kenjiro Shirane Kousuke Uranishi Aaron B. Bogutz Sanne M. Janssen Ayumu Suzuki Akihiko Okuda Haruhiko Koseki Matthew C. Lorincz Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
description	Germline genes are repressed by DNA methylation and histone marks. Here, the authors show that specific germline genes hypomethylated pre-implantation are enriched for PRC1.6, H2AK119ub1 and H3K9me3, which coordinately repress their expression.
format	article
author	Kentaro Mochizuki Jafar Sharif Kenjiro Shirane Kousuke Uranishi Aaron B. Bogutz Sanne M. Janssen Ayumu Suzuki Akihiko Okuda Haruhiko Koseki Matthew C. Lorincz
author_facet	Kentaro Mochizuki Jafar Sharif Kenjiro Shirane Kousuke Uranishi Aaron B. Bogutz Sanne M. Janssen Ayumu Suzuki Akihiko Okuda Haruhiko Koseki Matthew C. Lorincz
author_sort	Kentaro Mochizuki
title	Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
title_short	Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
title_full	Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
title_fullStr	Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
title_full_unstemmed	Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
title_sort	repression of germline genes by prc1.6 and setdb1 in the early embryo precedes dna methylation-mediated silencing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/006b6218cf214219b0b8f0d42574bd86
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Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

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