NEW ASPECTS OF ANTI-INFECTION IMMUNITY

Abstract. Four types of adaptive immune response which are regulated by different T-cell populations, namely Th1, Th2, Th17 and T regs have been described. At the first time classification is based on the difference in transcription factors but not due to diversity of cytokines produced. Each popula...

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Autor principal:	E. P. Kisseleva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	pathogens immunity phagocytes т-lymphocytes Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/006f2eb0221b4aa681c5ba29172aebdc
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spelling	oai:doaj.org-article:006f2eb0221b4aa681c5ba29172aebdc2021-11-22T07:09:45ZNEW ASPECTS OF ANTI-INFECTION IMMUNITY2220-76192313-739810.15789/2220-7619-2011-1-9-14https://doaj.org/article/006f2eb0221b4aa681c5ba29172aebdc2014-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/18https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Four types of adaptive immune response which are regulated by different T-cell populations, namely Th1, Th2, Th17 and T regs have been described. At the first time classification is based on the difference in transcription factors but not due to diversity of cytokines produced. Each population of T-lymphocytes possesses a set of unique transcription factors and directions of cell signaling. Each type of immune responses plays a key role in the protection against certain types of pathogens. The Th1-response is important against intracellular bacteria and fungi, the Th17 — against extracellular, the Th2 — against yeasts and protozoa. T-regulatory cells control all types of immune responses. Diversity of immune response mechanisms occurs due to involvement of different effector cells. The Th1-type of response is connected with macrophage activation, Th2-cells cooperate with B-lymphocytes as well as attract eosinophils and mast cells. Th17 lymphocytes stimulate neutrophils and epithelial cells. T-cell differentiation is directed by the cytokines produced by innate immune cells. Phagocytes recognize molecular patterns at the surface of pathogens via pattern-recognition receptors (PRR), become activated and synthesize cytokines. Pathogen plays important role in this process while instructing dendritic cells. Pathogen dials a special code from a number of phagocyte surface receptors, which is named as «combinatory» recognition. Phagocytes possess several different types of activation and synthesize different cytokines that direct T-lymphocytes to a certain type of differentiation.E. P. KisselevaSankt-Peterburg : NIIÈM imeni Pasteraarticlepathogensimmunityphagocytesт-lymphocytesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 1, Pp 9-14 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	pathogens immunity phagocytes т-lymphocytes Infectious and parasitic diseases RC109-216
spellingShingle	pathogens immunity phagocytes т-lymphocytes Infectious and parasitic diseases RC109-216 E. P. Kisseleva NEW ASPECTS OF ANTI-INFECTION IMMUNITY
description	Abstract. Four types of adaptive immune response which are regulated by different T-cell populations, namely Th1, Th2, Th17 and T regs have been described. At the first time classification is based on the difference in transcription factors but not due to diversity of cytokines produced. Each population of T-lymphocytes possesses a set of unique transcription factors and directions of cell signaling. Each type of immune responses plays a key role in the protection against certain types of pathogens. The Th1-response is important against intracellular bacteria and fungi, the Th17 — against extracellular, the Th2 — against yeasts and protozoa. T-regulatory cells control all types of immune responses. Diversity of immune response mechanisms occurs due to involvement of different effector cells. The Th1-type of response is connected with macrophage activation, Th2-cells cooperate with B-lymphocytes as well as attract eosinophils and mast cells. Th17 lymphocytes stimulate neutrophils and epithelial cells. T-cell differentiation is directed by the cytokines produced by innate immune cells. Phagocytes recognize molecular patterns at the surface of pathogens via pattern-recognition receptors (PRR), become activated and synthesize cytokines. Pathogen plays important role in this process while instructing dendritic cells. Pathogen dials a special code from a number of phagocyte surface receptors, which is named as «combinatory» recognition. Phagocytes possess several different types of activation and synthesize different cytokines that direct T-lymphocytes to a certain type of differentiation.
format	article
author	E. P. Kisseleva
author_facet	E. P. Kisseleva
author_sort	E. P. Kisseleva
title	NEW ASPECTS OF ANTI-INFECTION IMMUNITY
title_short	NEW ASPECTS OF ANTI-INFECTION IMMUNITY
title_full	NEW ASPECTS OF ANTI-INFECTION IMMUNITY
title_fullStr	NEW ASPECTS OF ANTI-INFECTION IMMUNITY
title_full_unstemmed	NEW ASPECTS OF ANTI-INFECTION IMMUNITY
title_sort	new aspects of anti-infection immunity
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/006f2eb0221b4aa681c5ba29172aebdc
work_keys_str_mv	AT epkisseleva newaspectsofantiinfectionimmunity
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NEW ASPECTS OF ANTI-INFECTION IMMUNITY

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