Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis

Persecutory ideations are self-referential delusions of being the target of malevolence despite a lack of evidence. Wisner et al. (2021) found that reduced connectivity between the left frontoparietal (lFP) network and parts of the orbitofrontal cortex (OFC) correlated with increased persecutory beh...

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Autores principales:	Lingyan Yu, Rebecca Kazinka, Danielle Pratt, Anita Kwashie, Angus W. MacDonald
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	persecutory ideation psychosis resting-state networks prefrontal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0070a6cfd9854e05a3538bc5dc0f0d96
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spelling	oai:doaj.org-article:0070a6cfd9854e05a3538bc5dc0f0d962021-11-25T16:58:23ZResting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis10.3390/brainsci111114902076-3425https://doaj.org/article/0070a6cfd9854e05a3538bc5dc0f0d962021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1490https://doaj.org/toc/2076-3425Persecutory ideations are self-referential delusions of being the target of malevolence despite a lack of evidence. Wisner et al. (2021) found that reduced connectivity between the left frontoparietal (lFP) network and parts of the orbitofrontal cortex (OFC) correlated with increased persecutory behaviors among psychotic patients performing in an economic social decision-making task that can measure the anticipation of a partner’s spiteful behavior. If this pattern could be observed in the resting state, it would suggest a functional-structural prior predisposing individuals to persecutory ideation. Forty-four patients in the early course of a psychotic disorder provided data for resting-state functional connectivity magnetic resonance imaging across nine brain networks that included the FP network and a similar OFC region. As predicted, we found a significant and negative correlation between the lFP–OFC at rest and the level of suspicious mistrust on the decision-making task using a within-group correlational design. Additionally, self-reported persecutory ideation correlated significantly with the connectivity between the right frontoparietal (rFP) network and the OFC. We extended the previous finding of reduced connectivity between the lFP network and the OFC in psychosis patients to the resting state, and observed a possible hemispheric difference, such that greater rFP–OFC connectivity predicted elevated self-reported persecutory ideation, suggesting potential differences between the lFP and rFP roles in persecutory social interactions.Lingyan YuRebecca KazinkaDanielle PrattAnita KwashieAngus W. MacDonaldMDPI AGarticlepersecutory ideationpsychosisresting-state networksprefrontalNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1490, p 1490 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	persecutory ideation psychosis resting-state networks prefrontal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	persecutory ideation psychosis resting-state networks prefrontal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lingyan Yu Rebecca Kazinka Danielle Pratt Anita Kwashie Angus W. MacDonald Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
description	Persecutory ideations are self-referential delusions of being the target of malevolence despite a lack of evidence. Wisner et al. (2021) found that reduced connectivity between the left frontoparietal (lFP) network and parts of the orbitofrontal cortex (OFC) correlated with increased persecutory behaviors among psychotic patients performing in an economic social decision-making task that can measure the anticipation of a partner’s spiteful behavior. If this pattern could be observed in the resting state, it would suggest a functional-structural prior predisposing individuals to persecutory ideation. Forty-four patients in the early course of a psychotic disorder provided data for resting-state functional connectivity magnetic resonance imaging across nine brain networks that included the FP network and a similar OFC region. As predicted, we found a significant and negative correlation between the lFP–OFC at rest and the level of suspicious mistrust on the decision-making task using a within-group correlational design. Additionally, self-reported persecutory ideation correlated significantly with the connectivity between the right frontoparietal (rFP) network and the OFC. We extended the previous finding of reduced connectivity between the lFP network and the OFC in psychosis patients to the resting state, and observed a possible hemispheric difference, such that greater rFP–OFC connectivity predicted elevated self-reported persecutory ideation, suggesting potential differences between the lFP and rFP roles in persecutory social interactions.
format	article
author	Lingyan Yu Rebecca Kazinka Danielle Pratt Anita Kwashie Angus W. MacDonald
author_facet	Lingyan Yu Rebecca Kazinka Danielle Pratt Anita Kwashie Angus W. MacDonald
author_sort	Lingyan Yu
title	Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
title_short	Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
title_full	Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
title_fullStr	Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
title_full_unstemmed	Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis
title_sort	resting-state networks associated with behavioral and self-reported measures of persecutory ideation in psychosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0070a6cfd9854e05a3538bc5dc0f0d96
work_keys_str_mv	AT lingyanyu restingstatenetworksassociatedwithbehavioralandselfreportedmeasuresofpersecutoryideationinpsychosis AT rebeccakazinka restingstatenetworksassociatedwithbehavioralandselfreportedmeasuresofpersecutoryideationinpsychosis AT daniellepratt restingstatenetworksassociatedwithbehavioralandselfreportedmeasuresofpersecutoryideationinpsychosis AT anitakwashie restingstatenetworksassociatedwithbehavioralandselfreportedmeasuresofpersecutoryideationinpsychosis AT anguswmacdonald restingstatenetworksassociatedwithbehavioralandselfreportedmeasuresofpersecutoryideationinpsychosis
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Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis

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