Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence

Patrick Wang,1 Eric K Chin,2 David Almeida3 1School of Medicine, Queen’s University, Kingston, Ontario, Canada; 2Retina Consultants of Southern California, Redlands, CA, USA; 3Erie Retinal Surgery, Erie, PA, USACorrespondence: David AlmeidaErie Retinal Surgery, 300 State Street, Suite 201,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang P, Chin EK, Almeida D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	antioxidant reactive oxygen species retina Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/007222c3910b43c7b36ff5cfa7165107
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:007222c3910b43c7b36ff5cfa7165107
record_format	dspace
spelling	oai:doaj.org-article:007222c3910b43c7b36ff5cfa71651072021-12-02T15:52:52ZAntioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence1177-5483https://doaj.org/article/007222c3910b43c7b36ff5cfa71651072021-04-01T00:00:00Zhttps://www.dovepress.com/antioxidants-for-the-treatment-of-retinal-disease-summary-of-recent-ev-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Patrick Wang,1 Eric K Chin,2 David Almeida3 1School of Medicine, Queen’s University, Kingston, Ontario, Canada; 2Retina Consultants of Southern California, Redlands, CA, USA; 3Erie Retinal Surgery, Erie, PA, USACorrespondence: David AlmeidaErie Retinal Surgery, 300 State Street, Suite 201, Erie, PA, 16507, USATel +1 814 456-4241Fax +1 814 453-3354Email drpa@pm.meAbstract: Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high metabolic demand. The formation of reactive oxygen species occurs primarily from the mitochondrial respiratory chain as well as several enzymatic and oxidation reactions that occur in the neurosensory retina and retinal pigment epithelium. This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. The aim of this narrative review is to describe the mechanisms of retinal oxidative stress and summarize the current available evidence for antioxidants as a treatment for vitreoretinal disorders.Keywords: antioxidant, reactive oxygen species, retinaWang PChin EKAlmeida DDove Medical Pressarticleantioxidantreactive oxygen speciesretinaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1621-1628 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant reactive oxygen species retina Ophthalmology RE1-994
spellingShingle	antioxidant reactive oxygen species retina Ophthalmology RE1-994 Wang P Chin EK Almeida D Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
description	Patrick Wang,1 Eric K Chin,2 David Almeida3 1School of Medicine, Queen’s University, Kingston, Ontario, Canada; 2Retina Consultants of Southern California, Redlands, CA, USA; 3Erie Retinal Surgery, Erie, PA, USACorrespondence: David AlmeidaErie Retinal Surgery, 300 State Street, Suite 201, Erie, PA, 16507, USATel +1 814 456-4241Fax +1 814 453-3354Email drpa@pm.meAbstract: Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high metabolic demand. The formation of reactive oxygen species occurs primarily from the mitochondrial respiratory chain as well as several enzymatic and oxidation reactions that occur in the neurosensory retina and retinal pigment epithelium. This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. The aim of this narrative review is to describe the mechanisms of retinal oxidative stress and summarize the current available evidence for antioxidants as a treatment for vitreoretinal disorders.Keywords: antioxidant, reactive oxygen species, retina
format	article
author	Wang P Chin EK Almeida D
author_facet	Wang P Chin EK Almeida D
author_sort	Wang P
title	Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
title_short	Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
title_full	Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
title_fullStr	Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
title_full_unstemmed	Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
title_sort	antioxidants for the treatment of retinal disease: summary of recent evidence
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/007222c3910b43c7b36ff5cfa7165107
work_keys_str_mv	AT wangp antioxidantsforthetreatmentofretinaldiseasesummaryofrecentevidence AT chinek antioxidantsforthetreatmentofretinaldiseasesummaryofrecentevidence AT almeidad antioxidantsforthetreatmentofretinaldiseasesummaryofrecentevidence
_version_	1718385550192279552

Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence

Ejemplares similares