Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice

Abstract As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut microbiota have emerged as a promising contributor to individual differences in the risk of illness, disease course, and treatment response. Here, we employed chronic mild social defeat stress and 16S...

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Autores principales:	Kara D. McGaughey, Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguiz, Michael D. Kritzer, Angel V. Peterchev, Jeffrey Roach, William C. Wetsel, Douglas E. Williamson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0072fb77cdb046e390213756467265fd
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spelling	oai:doaj.org-article:0072fb77cdb046e390213756467265fd2021-12-02T15:09:40ZRelative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice10.1038/s41598-019-40140-52045-2322https://doaj.org/article/0072fb77cdb046e390213756467265fd2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-40140-5https://doaj.org/toc/2045-2322Abstract As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut microbiota have emerged as a promising contributor to individual differences in the risk of illness, disease course, and treatment response. Here, we employed chronic mild social defeat stress and 16S rRNA gene metagenomic sequencing to investigate the role of microbial composition in mediating anxiety- and depressive-like behavior. In socially defeated animals, we found significant reductions in the overall diversity and relative abundances of numerous bacterial genera, including Akkermansia spp., that positively correlated with behavioral metrics of both anxiety and depression. Functional analyses predicted a reduced frequency of signaling molecule pathways, including G-protein-coupled receptors, in defeated animals. Collectively, our data suggest that shifts in microbial composition may play a role in the pathogenesis of anxiety and depression.Kara D. McGaugheyTulay Yilmaz-SwensonNourhan M. ElsayedDianne A. CruzRamona M. RodriguizMichael D. KritzerAngel V. PeterchevJeffrey RoachWilliam C. WetselDouglas E. WilliamsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kara D. McGaughey Tulay Yilmaz-Swenson Nourhan M. Elsayed Dianne A. Cruz Ramona M. Rodriguiz Michael D. Kritzer Angel V. Peterchev Jeffrey Roach William C. Wetsel Douglas E. Williamson Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
description	Abstract As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut microbiota have emerged as a promising contributor to individual differences in the risk of illness, disease course, and treatment response. Here, we employed chronic mild social defeat stress and 16S rRNA gene metagenomic sequencing to investigate the role of microbial composition in mediating anxiety- and depressive-like behavior. In socially defeated animals, we found significant reductions in the overall diversity and relative abundances of numerous bacterial genera, including Akkermansia spp., that positively correlated with behavioral metrics of both anxiety and depression. Functional analyses predicted a reduced frequency of signaling molecule pathways, including G-protein-coupled receptors, in defeated animals. Collectively, our data suggest that shifts in microbial composition may play a role in the pathogenesis of anxiety and depression.
format	article
author	Kara D. McGaughey Tulay Yilmaz-Swenson Nourhan M. Elsayed Dianne A. Cruz Ramona M. Rodriguiz Michael D. Kritzer Angel V. Peterchev Jeffrey Roach William C. Wetsel Douglas E. Williamson
author_facet	Kara D. McGaughey Tulay Yilmaz-Swenson Nourhan M. Elsayed Dianne A. Cruz Ramona M. Rodriguiz Michael D. Kritzer Angel V. Peterchev Jeffrey Roach William C. Wetsel Douglas E. Williamson
author_sort	Kara D. McGaughey
title	Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
title_short	Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
title_full	Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
title_fullStr	Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
title_full_unstemmed	Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
title_sort	relative abundance of akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0072fb77cdb046e390213756467265fd
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Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice

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