Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats

Abstract Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety of diseases. Reduction of inflammatory response was proposed as one of the molecular mechanisms for how CR exerts beneficial effects. The present study investigated the effects of CR on p...

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Autores principales:	Yue Liu, Yuan Ni, Wei Zhang, Yu-E Sun, Zhengliang Ma, Xiaoping Gu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0077ee0add694da09f567cfaaf9fd93d
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spelling	oai:doaj.org-article:0077ee0add694da09f567cfaaf9fd93d2021-12-02T16:06:55ZAntinociceptive effects of caloric restriction on post-incisional pain in nonobese rats10.1038/s41598-017-01909-82045-2322https://doaj.org/article/0077ee0add694da09f567cfaaf9fd93d2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01909-8https://doaj.org/toc/2045-2322Abstract Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety of diseases. Reduction of inflammatory response was proposed as one of the molecular mechanisms for how CR exerts beneficial effects. The present study investigated the effects of CR on postoperative pain in rats. Adult nonobese rats were divided into two dietary groups, an ad libitum fed group (AL) and a caloric restriction group (CR) that was provided with 60% of the food intake of AL rats. After 6 weeks, the effects of CR on pain behaviors and inflammation induced by plantar incision were examined. CR rats displayed significantly reduced nonevoked pain, mechanical allodynia and thermal hyperalgesia induced by incision, and showed decreased levels of pro-inflammatory cytokines in serum, peri-incisional skin tissue and ipsilateral spinal cord dorsal horn at 6 h and 24 h after incision. The analgesic efficiency of parecoxib and morphine, two agents widely used for the management of postoperative pain clinically, was reinforced by CR. Together, CR generates antinociceptive effects on postoperative incisional pain in rats, perhaps providing some improvement of QOL in patients with postoperative pain, and the beneficial effects may be attributable to the inhibition of excessive inflammation induced by surgical injury.Yue LiuYuan NiWei ZhangYu-E SunZhengliang MaXiaoping GuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yue Liu Yuan Ni Wei Zhang Yu-E Sun Zhengliang Ma Xiaoping Gu Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
description	Abstract Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety of diseases. Reduction of inflammatory response was proposed as one of the molecular mechanisms for how CR exerts beneficial effects. The present study investigated the effects of CR on postoperative pain in rats. Adult nonobese rats were divided into two dietary groups, an ad libitum fed group (AL) and a caloric restriction group (CR) that was provided with 60% of the food intake of AL rats. After 6 weeks, the effects of CR on pain behaviors and inflammation induced by plantar incision were examined. CR rats displayed significantly reduced nonevoked pain, mechanical allodynia and thermal hyperalgesia induced by incision, and showed decreased levels of pro-inflammatory cytokines in serum, peri-incisional skin tissue and ipsilateral spinal cord dorsal horn at 6 h and 24 h after incision. The analgesic efficiency of parecoxib and morphine, two agents widely used for the management of postoperative pain clinically, was reinforced by CR. Together, CR generates antinociceptive effects on postoperative incisional pain in rats, perhaps providing some improvement of QOL in patients with postoperative pain, and the beneficial effects may be attributable to the inhibition of excessive inflammation induced by surgical injury.
format	article
author	Yue Liu Yuan Ni Wei Zhang Yu-E Sun Zhengliang Ma Xiaoping Gu
author_facet	Yue Liu Yuan Ni Wei Zhang Yu-E Sun Zhengliang Ma Xiaoping Gu
author_sort	Yue Liu
title	Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
title_short	Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
title_full	Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
title_fullStr	Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
title_full_unstemmed	Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
title_sort	antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0077ee0add694da09f567cfaaf9fd93d
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Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats

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