Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca<sup>2+</sup>-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca<sup>2+</sup>-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although Ca2+ plays a pivotal role in ER functi...

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Bibliographic Details
Main Authors: Martin Weichert, José Guirao-Abad, Vishukumar Aimanianda, Karthik Krishnan, Christina Grisham, Patrick Snyder, Alex Sheehan, Ruthvik R. Abbu, Hong Liu, Scott G. Filler, Eric I. Gruenstein, Jean-Paul Latgé, David S. Askew
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Aspergillus fumigatus
UPR
HacA
ER stress
calcium
SERCA
Microbiology
QR1-502
Online Access:https://doaj.org/article/007980a41c5748d0a0a5bb8f3bb9a8fa
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