Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study

Background: No study has explored the modification effect of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and risk of cardiovascular disease (CVD) so far. We aim to examine the effect of ICVHMs on the association between exposure to famine early in life and...

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Autores principales:	Xiong Ding, Jinfeng Li, Ying Wu, Peng Yang, Dandan Zhao, Xiaojie Yuan, Shuohua Chen, Xiaoyan Luo, Yun Li, Shouling Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fetal ideal cardiovascular health metrics China famine cardiovascular disease cohort study Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/007a89c8bf84496e9cabdb5caf547047
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spelling	oai:doaj.org-article:007a89c8bf84496e9cabdb5caf5470472021-11-04T06:31:40ZIdeal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study2297-055X10.3389/fcvm.2021.751910https://doaj.org/article/007a89c8bf84496e9cabdb5caf5470472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.751910/fullhttps://doaj.org/toc/2297-055XBackground: No study has explored the modification effect of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and risk of cardiovascular disease (CVD) so far. We aim to examine the effect of ICVHMs on the association between exposure to famine early in life and the risk of CVD in adulthood.Methods: A total of 61,527 participants free of CVD were included in this study from the Kailuan Study. All participants were divided into three groups, included nonexposed, fetal-exposed, and childhood-exposed groups. Cox regression was used to estimate the effect of famine exposure and ICVHMs on CVD risk.Results: After a median of 13.0 (12.7–13.2) years follow-up, 4,814 incident CVD cases were identified. Compared with nonexposed participants, the CVD risk increased in participants with fetal famine exposure (hazard ratio [HR]: 1.21; 95% CI: 1.07–1.37), but not in childhood famine-exposed participants. After stratifying by the number of ICVHMs, the increased CVD risk associated with fetal famine exposure was only observed in participants with less ICVHMs ( ≤ 2) (HR: 1.30; 95% CI: 1.11–1.52, P for interaction=0.008), but disappeared in those with three or more ICVHMs. The modified effect of ICVHMs was sex specific (P for sex interaction = 0.031).Conclusions: Exposing to famine in the fetal period could increase the risk of CVD in late life; however, ICVHMs might modify the effect of famine exposure on CVD risk, especially in men.Xiong DingJinfeng LiYing WuPeng YangDandan ZhaoXiaojie YuanShuohua ChenXiaoyan LuoYun LiShouling WuFrontiers Media S.A.articlefetalideal cardiovascular health metricsChina faminecardiovascular diseasecohort studyDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fetal ideal cardiovascular health metrics China famine cardiovascular disease cohort study Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	fetal ideal cardiovascular health metrics China famine cardiovascular disease cohort study Diseases of the circulatory (Cardiovascular) system RC666-701 Xiong Ding Jinfeng Li Ying Wu Peng Yang Dandan Zhao Xiaojie Yuan Shuohua Chen Xiaoyan Luo Yun Li Shouling Wu Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
description	Background: No study has explored the modification effect of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and risk of cardiovascular disease (CVD) so far. We aim to examine the effect of ICVHMs on the association between exposure to famine early in life and the risk of CVD in adulthood.Methods: A total of 61,527 participants free of CVD were included in this study from the Kailuan Study. All participants were divided into three groups, included nonexposed, fetal-exposed, and childhood-exposed groups. Cox regression was used to estimate the effect of famine exposure and ICVHMs on CVD risk.Results: After a median of 13.0 (12.7–13.2) years follow-up, 4,814 incident CVD cases were identified. Compared with nonexposed participants, the CVD risk increased in participants with fetal famine exposure (hazard ratio [HR]: 1.21; 95% CI: 1.07–1.37), but not in childhood famine-exposed participants. After stratifying by the number of ICVHMs, the increased CVD risk associated with fetal famine exposure was only observed in participants with less ICVHMs ( ≤ 2) (HR: 1.30; 95% CI: 1.11–1.52, P for interaction=0.008), but disappeared in those with three or more ICVHMs. The modified effect of ICVHMs was sex specific (P for sex interaction = 0.031).Conclusions: Exposing to famine in the fetal period could increase the risk of CVD in late life; however, ICVHMs might modify the effect of famine exposure on CVD risk, especially in men.
format	article
author	Xiong Ding Jinfeng Li Ying Wu Peng Yang Dandan Zhao Xiaojie Yuan Shuohua Chen Xiaoyan Luo Yun Li Shouling Wu
author_facet	Xiong Ding Jinfeng Li Ying Wu Peng Yang Dandan Zhao Xiaojie Yuan Shuohua Chen Xiaoyan Luo Yun Li Shouling Wu
author_sort	Xiong Ding
title	Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
title_short	Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
title_full	Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
title_fullStr	Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
title_full_unstemmed	Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study
title_sort	ideal cardiovascular health metrics modify the association between exposure to chinese famine in fetal and cardiovascular disease: a prospective cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/007a89c8bf84496e9cabdb5caf547047
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Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study

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