Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:007e4295faa9467ba2f947c4d342dc0a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:007e4295faa9467ba2f947c4d342dc0a2021-12-02T14:39:29ZInactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma10.1038/ncomms124932041-1723https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12493https://doaj.org/toc/2041-1723Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas.Patrizia CammareriAidan M. RoseDavid F. VincentJun WangAi NaganoSilvana LibertiniRachel A. RidgwayDimitris AthineosPhilip J. CoatesAngela McHughCeline PourreyronJasbani H. S. DayalJonas LarssonSimone WeidlichLindsay C. SpenderGopal P. SapkotaKarin J. PurdieCharlotte M. ProbyCatherine A. HarwoodIrene M. LeighHans CleversNick BarkerStefan KarlssonCatrin PritchardRichard MaraisClaude ChelalaAndrew P. SouthOwen J. SansomGareth J. InmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Patrizia Cammareri Aidan M. Rose David F. Vincent Jun Wang Ai Nagano Silvana Libertini Rachel A. Ridgway Dimitris Athineos Philip J. Coates Angela McHugh Celine Pourreyron Jasbani H. S. Dayal Jonas Larsson Simone Weidlich Lindsay C. Spender Gopal P. Sapkota Karin J. Purdie Charlotte M. Proby Catherine A. Harwood Irene M. Leigh Hans Clevers Nick Barker Stefan Karlsson Catrin Pritchard Richard Marais Claude Chelala Andrew P. South Owen J. Sansom Gareth J. Inman Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| description |
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas. |
| format |
article |
| author |
Patrizia Cammareri Aidan M. Rose David F. Vincent Jun Wang Ai Nagano Silvana Libertini Rachel A. Ridgway Dimitris Athineos Philip J. Coates Angela McHugh Celine Pourreyron Jasbani H. S. Dayal Jonas Larsson Simone Weidlich Lindsay C. Spender Gopal P. Sapkota Karin J. Purdie Charlotte M. Proby Catherine A. Harwood Irene M. Leigh Hans Clevers Nick Barker Stefan Karlsson Catrin Pritchard Richard Marais Claude Chelala Andrew P. South Owen J. Sansom Gareth J. Inman |
| author_facet |
Patrizia Cammareri Aidan M. Rose David F. Vincent Jun Wang Ai Nagano Silvana Libertini Rachel A. Ridgway Dimitris Athineos Philip J. Coates Angela McHugh Celine Pourreyron Jasbani H. S. Dayal Jonas Larsson Simone Weidlich Lindsay C. Spender Gopal P. Sapkota Karin J. Purdie Charlotte M. Proby Catherine A. Harwood Irene M. Leigh Hans Clevers Nick Barker Stefan Karlsson Catrin Pritchard Richard Marais Claude Chelala Andrew P. South Owen J. Sansom Gareth J. Inman |
| author_sort |
Patrizia Cammareri |
| title |
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| title_short |
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| title_full |
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| title_fullStr |
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| title_full_unstemmed |
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| title_sort |
inactivation of tgfβ receptors in stem cells drives cutaneous squamous cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a |
| work_keys_str_mv |
AT patriziacammareri inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT aidanmrose inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT davidfvincent inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT junwang inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT ainagano inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT silvanalibertini inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT rachelaridgway inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT dimitrisathineos inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT philipjcoates inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT angelamchugh inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT celinepourreyron inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT jasbanihsdayal inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT jonaslarsson inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT simoneweidlich inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT lindsaycspender inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT gopalpsapkota inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT karinjpurdie inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT charlottemproby inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT catherineaharwood inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT irenemleigh inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT hansclevers inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT nickbarker inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT stefankarlsson inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT catrinpritchard inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT richardmarais inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT claudechelala inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT andrewpsouth inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT owenjsansom inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma AT garethjinman inactivationoftgfbreceptorsinstemcellsdrivescutaneoussquamouscellcarcinoma |
| _version_ |
1718390573927235584 |