Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism

Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducin...

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Autores principales:	Scott M. MacKenzie, Hannah Saunders, Josie C. van Kralingen, Stacy Robertson, Alexandra Riddell, Maria-Christina Zennaro, Eleanor Davies
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	primary aldosteronism microRNA aldosterone circulating biomarker adrenocortical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/007eadf0bb6148fb928a81081a8f6a47
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id	oai:doaj.org-article:007eadf0bb6148fb928a81081a8f6a47
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spelling	oai:doaj.org-article:007eadf0bb6148fb928a81081a8f6a472021-11-11T15:28:10ZCirculating microRNAs as Diagnostic Markers in Primary Aldosteronism10.3390/cancers132153122072-6694https://doaj.org/article/007eadf0bb6148fb928a81081a8f6a472021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5312https://doaj.org/toc/2072-6694Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome.Scott M. MacKenzieHannah SaundersJosie C. van KralingenStacy RobertsonAlexandra RiddellMaria-Christina ZennaroEleanor DaviesMDPI AGarticleprimary aldosteronismmicroRNAaldosteronecirculatingbiomarkeradrenocorticalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5312, p 5312 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary aldosteronism microRNA aldosterone circulating biomarker adrenocortical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	primary aldosteronism microRNA aldosterone circulating biomarker adrenocortical Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Scott M. MacKenzie Hannah Saunders Josie C. van Kralingen Stacy Robertson Alexandra Riddell Maria-Christina Zennaro Eleanor Davies Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
description	Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome.
format	article
author	Scott M. MacKenzie Hannah Saunders Josie C. van Kralingen Stacy Robertson Alexandra Riddell Maria-Christina Zennaro Eleanor Davies
author_facet	Scott M. MacKenzie Hannah Saunders Josie C. van Kralingen Stacy Robertson Alexandra Riddell Maria-Christina Zennaro Eleanor Davies
author_sort	Scott M. MacKenzie
title	Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
title_short	Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
title_full	Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
title_fullStr	Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
title_full_unstemmed	Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
title_sort	circulating micrornas as diagnostic markers in primary aldosteronism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/007eadf0bb6148fb928a81081a8f6a47
work_keys_str_mv	AT scottmmackenzie circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT hannahsaunders circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT josiecvankralingen circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT stacyrobertson circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT alexandrariddell circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT mariachristinazennaro circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism AT eleanordavies circulatingmicrornasasdiagnosticmarkersinprimaryaldosteronism
_version_	1718435221815164928

Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism

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