Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition
Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N fastens CENP-A to the DNA.
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Nature Portfolio
2017
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oai:doaj.org-article:007ef2a91d124eb6baa7acd0387157c42021-12-02T17:06:25ZCentromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition10.1038/ncomms157752041-1723https://doaj.org/article/007ef2a91d124eb6baa7acd0387157c42017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15775https://doaj.org/toc/2041-1723Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N fastens CENP-A to the DNA.Lucie Y. GuoPraveen Kumar AlluLevani ZandarashviliKara L. McKinleyNikolina SekulicJennine M. Dawicki-McKennaDaniele FachinettiGlennis A. LogsdonRyan M. JamiolkowskiDon W. ClevelandIain M. CheesemanBen E. BlackNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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spellingShingle |
Science Q Lucie Y. Guo Praveen Kumar Allu Levani Zandarashvili Kara L. McKinley Nikolina Sekulic Jennine M. Dawicki-McKenna Daniele Fachinetti Glennis A. Logsdon Ryan M. Jamiolkowski Don W. Cleveland Iain M. Cheeseman Ben E. Black Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
description |
Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N fastens CENP-A to the DNA. |
format |
article |
author |
Lucie Y. Guo Praveen Kumar Allu Levani Zandarashvili Kara L. McKinley Nikolina Sekulic Jennine M. Dawicki-McKenna Daniele Fachinetti Glennis A. Logsdon Ryan M. Jamiolkowski Don W. Cleveland Iain M. Cheeseman Ben E. Black |
author_facet |
Lucie Y. Guo Praveen Kumar Allu Levani Zandarashvili Kara L. McKinley Nikolina Sekulic Jennine M. Dawicki-McKenna Daniele Fachinetti Glennis A. Logsdon Ryan M. Jamiolkowski Don W. Cleveland Iain M. Cheeseman Ben E. Black |
author_sort |
Lucie Y. Guo |
title |
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
title_short |
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
title_full |
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
title_fullStr |
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
title_full_unstemmed |
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition |
title_sort |
centromeres are maintained by fastening cenp-a to dna and directing an arginine anchor-dependent nucleosome transition |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/007ef2a91d124eb6baa7acd0387157c4 |
work_keys_str_mv |
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1718381594559905792 |