Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives

Mohammad Alizadeh,1,* Moludi Jalal,2 Khodaei Hamed,3 Amir Saber,2,* Sorayya Kheirouri,1 Fatemeh Pourteymour Fard Tabrizi,3 Negin Kamari2 1Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Department of Nutritional Sciences, School of Nutritional Sciences and Food Techn...

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Autores principales:	Alizadeh M, Jalal M, Hamed K, Saber A, Kheirouri S, Pourteymour Fard Tabrizi F, Kamari N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	anti-inflammatory antimicrobial furans benzofurans furan natural derivatives Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/008230d3f96b474f931b86fa59e84369
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spelling	oai:doaj.org-article:008230d3f96b474f931b86fa59e843692021-12-02T08:42:49ZRecent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives1178-7031https://doaj.org/article/008230d3f96b474f931b86fa59e843692020-08-01T00:00:00Zhttps://www.dovepress.com/recent-updates-on-anti-inflammatory-and-antimicrobial-effects-of-furan-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Mohammad Alizadeh,1,* Moludi Jalal,2 Khodaei Hamed,3 Amir Saber,2,* Sorayya Kheirouri,1 Fatemeh Pourteymour Fard Tabrizi,3 Negin Kamari2 1Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran*These authors contributed equally to this workCorrespondence: Moludi JalalDepartment of Nutrition, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Isar Sq., Across from Farabi Hospital, Kermanshah, IranTel +98-83 37102009Fax +98-83 37102002Email jalal.moludi68@gmail.comKhodaei HamedDepartment of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, IranEmail hamedkhodaei@yahoo.comAbstract: The furan nucleus is found in a large number of biologically active materials. In recent years, many natural furan derivatives were isolated and their biological effects were investigated. In this review, we focused on the anti-inflammatory and antimicrobial effects of some natural furans and discussed their effects on the immune system. Our investigation revealed that furan natural derivatives have effective antioxidant activities and exert regulatory effects on various cellular activities by modifying some signaling pathways such as MAPK (mitogen-activated Protein Kinase) and PPAR-ɣ (peroxisome proliferator-activated receptor gamma). The antimicrobial activity of these natural compounds was performed through selective inhibition of microbial growth and modification of enzymes. Further studies are needed for isolation and detection of different furan derivatives from natural compounds and investigation of their precise mechanisms for revealing health beneficial effects of these compounds.Keywords: anti-inflammatory, antimicrobial, furans, benzofurans, furan natural derivativesAlizadeh MJalal MHamed KSaber AKheirouri SPourteymour Fard Tabrizi FKamari NDove Medical Pressarticleanti-inflammatoryantimicrobialfuransbenzofuransfuran natural derivativesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 451-463 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-inflammatory antimicrobial furans benzofurans furan natural derivatives Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	anti-inflammatory antimicrobial furans benzofurans furan natural derivatives Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Alizadeh M Jalal M Hamed K Saber A Kheirouri S Pourteymour Fard Tabrizi F Kamari N Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
description	Mohammad Alizadeh,1,* Moludi Jalal,2 Khodaei Hamed,3 Amir Saber,2,* Sorayya Kheirouri,1 Fatemeh Pourteymour Fard Tabrizi,3 Negin Kamari2 1Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran*These authors contributed equally to this workCorrespondence: Moludi JalalDepartment of Nutrition, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Isar Sq., Across from Farabi Hospital, Kermanshah, IranTel +98-83 37102009Fax +98-83 37102002Email jalal.moludi68@gmail.comKhodaei HamedDepartment of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, IranEmail hamedkhodaei@yahoo.comAbstract: The furan nucleus is found in a large number of biologically active materials. In recent years, many natural furan derivatives were isolated and their biological effects were investigated. In this review, we focused on the anti-inflammatory and antimicrobial effects of some natural furans and discussed their effects on the immune system. Our investigation revealed that furan natural derivatives have effective antioxidant activities and exert regulatory effects on various cellular activities by modifying some signaling pathways such as MAPK (mitogen-activated Protein Kinase) and PPAR-ɣ (peroxisome proliferator-activated receptor gamma). The antimicrobial activity of these natural compounds was performed through selective inhibition of microbial growth and modification of enzymes. Further studies are needed for isolation and detection of different furan derivatives from natural compounds and investigation of their precise mechanisms for revealing health beneficial effects of these compounds.Keywords: anti-inflammatory, antimicrobial, furans, benzofurans, furan natural derivatives
format	article
author	Alizadeh M Jalal M Hamed K Saber A Kheirouri S Pourteymour Fard Tabrizi F Kamari N
author_facet	Alizadeh M Jalal M Hamed K Saber A Kheirouri S Pourteymour Fard Tabrizi F Kamari N
author_sort	Alizadeh M
title	Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
title_short	Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
title_full	Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
title_fullStr	Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
title_full_unstemmed	Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
title_sort	recent updates on anti-inflammatory and antimicrobial effects of furan natural derivatives
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/008230d3f96b474f931b86fa59e84369
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Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives

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