Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions

Abstract Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 ...

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Autores principales: Loes P. M. Duivenvoorde, Jochem Louisse, Nicole E. T. Pinckaers, Tien Nguyen, Meike van der Zande
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/008565ddf71e440da8235f0eb5f5e768
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