NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

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Autores principales: Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/0085ce66095d4d51b112d11335833dab
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spelling oai:doaj.org-article:0085ce66095d4d51b112d11335833dab2021-12-02T14:41:06ZNOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence10.1038/s41467-018-04283-92041-1723https://doaj.org/article/0085ce66095d4d51b112d11335833dab2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04283-9https://doaj.org/toc/2041-1723Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.Aled J. ParryMatthew HoareDóra BiharyRobert Hänsel-HertschStephen SmithKosuke TomimatsuElizabeth MannionAmy SmithPaula D’SantosI. Alasdair RussellShankar BalasubramanianHiroshi KimuraShamith A. SamarajiwaMasashi NaritaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aled J. Parry
Matthew Hoare
Dóra Bihary
Robert Hänsel-Hertsch
Stephen Smith
Kosuke Tomimatsu
Elizabeth Mannion
Amy Smith
Paula D’Santos
I. Alasdair Russell
Shankar Balasubramanian
Hiroshi Kimura
Shamith A. Samarajiwa
Masashi Narita
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
description Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.
format article
author Aled J. Parry
Matthew Hoare
Dóra Bihary
Robert Hänsel-Hertsch
Stephen Smith
Kosuke Tomimatsu
Elizabeth Mannion
Amy Smith
Paula D’Santos
I. Alasdair Russell
Shankar Balasubramanian
Hiroshi Kimura
Shamith A. Samarajiwa
Masashi Narita
author_facet Aled J. Parry
Matthew Hoare
Dóra Bihary
Robert Hänsel-Hertsch
Stephen Smith
Kosuke Tomimatsu
Elizabeth Mannion
Amy Smith
Paula D’Santos
I. Alasdair Russell
Shankar Balasubramanian
Hiroshi Kimura
Shamith A. Samarajiwa
Masashi Narita
author_sort Aled J. Parry
title NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
title_short NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
title_full NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
title_fullStr NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
title_full_unstemmed NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
title_sort notch-mediated non-cell autonomous regulation of chromatin structure during senescence
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0085ce66095d4d51b112d11335833dab
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