NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

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Bibliographic Details
Main Authors: Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/0085ce66095d4d51b112d11335833dab
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Internet

https://doaj.org/article/0085ce66095d4d51b112d11335833dab

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