Bimodal sensing of guidance cues in mechanically distinct microenvironments

Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.

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Autores principales: Erdem D. Tabdanov, Vikram V. Puram, Zaw Win, Ashab Alamgir, Patrick W. Alford, Paolo P. Provenzano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0089919579e3475c95e212fc5fe23d0a
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spelling oai:doaj.org-article:0089919579e3475c95e212fc5fe23d0a2021-12-02T16:49:39ZBimodal sensing of guidance cues in mechanically distinct microenvironments10.1038/s41467-018-07290-y2041-1723https://doaj.org/article/0089919579e3475c95e212fc5fe23d0a2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07290-yhttps://doaj.org/toc/2041-1723Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.Erdem D. TabdanovVikram V. PuramZaw WinAshab AlamgirPatrick W. AlfordPaolo P. ProvenzanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
Bimodal sensing of guidance cues in mechanically distinct microenvironments
description Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.
format article
author Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
author_facet Erdem D. Tabdanov
Vikram V. Puram
Zaw Win
Ashab Alamgir
Patrick W. Alford
Paolo P. Provenzano
author_sort Erdem D. Tabdanov
title Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_short Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_full Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_fullStr Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_full_unstemmed Bimodal sensing of guidance cues in mechanically distinct microenvironments
title_sort bimodal sensing of guidance cues in mechanically distinct microenvironments
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0089919579e3475c95e212fc5fe23d0a
work_keys_str_mv AT erdemdtabdanov bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT vikramvpuram bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT zawwin bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT ashabalamgir bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT patrickwalford bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
AT paolopprovenzano bimodalsensingofguidancecuesinmechanicallydistinctmicroenvironments
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