THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING

Nowadays in chronic diseases structure mental derangement leading to disability and mortality of population comes to the front. As a result of illicit traffic of drugs extension, using psychoactive medicinal agents by drug abusers for intensification of intoxication and alleviation of abstinence syn...

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Autores principales:	A. M. Lazitskaya, N. V. Chmelevskaya, E. A. Illarionova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	tofisopam fluoxetine eluent system thin-layer chromatography combined compositions Science Q
Acceso en línea:	https://doaj.org/article/008a682397ee41b1a11c562768c90591
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spelling	oai:doaj.org-article:008a682397ee41b1a11c562768c905912021-11-23T06:14:37ZTHIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING2541-94202587-959610.12737/article_59a614fc20c669.86359679https://doaj.org/article/008a682397ee41b1a11c562768c905912017-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/623https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Nowadays in chronic diseases structure mental derangement leading to disability and mortality of population comes to the front. As a result of illicit traffic of drugs extension, using psychoactive medicinal agents by drug abusers for intensification of intoxication and alleviation of abstinence syndrome has been fixed to increase. It results in occurrence of poisonings. The main goal of the work is a development of strategy of chemical-toxicological analysis of psychoactive medical agents useable for combined poisonings via thin-layer chromatography method. The research offers the results of studying the chromatographic behaviour of tofisopam and fluoxetine combined with psychoactive medicinal agents on chromatographic plates "Sorbfil UV-254" and "Armcorb UV-254" in general solvent systems. It is shown that separation of psychoactive substances does not occur accurate enough. Therefore, it is necessary to develop particular chromatographic systems. A system of composition of toluol - acetone - 25% solution of ammonia is revealed and can be recommended in screening while carrying out a nondirectional analysis of tofisopam and fluoxetine. In this system, all combinations under research are detected. A search of particular chromatographic systems was carried out by changing the quantity of toluol, acetone and ammonia. It is established that solvent systems of toluol - acetone - 25% solution of ammonia in a ratio 50:50:1 and 50:50:4 are optimal for identification of combinations with tofisopam and fluoxetine accordingly. The developed method allows detecting tofisopam and fluoxetine in urine on a preliminary step of research both individually and in combinations with psychoactive medicinal agents.A. M. LazitskayaN. V. ChmelevskayaE. A. IllarionovaScientific Сentre for Family Health and Human Reproduction Problemsarticletofisopamfluoxetineeluent systemthin-layer chromatographycombined compositionsScienceQRUActa Biomedica Scientifica, Vol 2, Iss 2, Pp 74-79 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	tofisopam fluoxetine eluent system thin-layer chromatography combined compositions Science Q
spellingShingle	tofisopam fluoxetine eluent system thin-layer chromatography combined compositions Science Q A. M. Lazitskaya N. V. Chmelevskaya E. A. Illarionova THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
description	Nowadays in chronic diseases structure mental derangement leading to disability and mortality of population comes to the front. As a result of illicit traffic of drugs extension, using psychoactive medicinal agents by drug abusers for intensification of intoxication and alleviation of abstinence syndrome has been fixed to increase. It results in occurrence of poisonings. The main goal of the work is a development of strategy of chemical-toxicological analysis of psychoactive medical agents useable for combined poisonings via thin-layer chromatography method. The research offers the results of studying the chromatographic behaviour of tofisopam and fluoxetine combined with psychoactive medicinal agents on chromatographic plates "Sorbfil UV-254" and "Armcorb UV-254" in general solvent systems. It is shown that separation of psychoactive substances does not occur accurate enough. Therefore, it is necessary to develop particular chromatographic systems. A system of composition of toluol - acetone - 25% solution of ammonia is revealed and can be recommended in screening while carrying out a nondirectional analysis of tofisopam and fluoxetine. In this system, all combinations under research are detected. A search of particular chromatographic systems was carried out by changing the quantity of toluol, acetone and ammonia. It is established that solvent systems of toluol - acetone - 25% solution of ammonia in a ratio 50:50:1 and 50:50:4 are optimal for identification of combinations with tofisopam and fluoxetine accordingly. The developed method allows detecting tofisopam and fluoxetine in urine on a preliminary step of research both individually and in combinations with psychoactive medicinal agents.
format	article
author	A. M. Lazitskaya N. V. Chmelevskaya E. A. Illarionova
author_facet	A. M. Lazitskaya N. V. Chmelevskaya E. A. Illarionova
author_sort	A. M. Lazitskaya
title	THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
title_short	THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
title_full	THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
title_fullStr	THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
title_full_unstemmed	THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING
title_sort	thin-layer chromatography in the analysis of psychotropic agents at combined poisoning
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/008a682397ee41b1a11c562768c90591
work_keys_str_mv	AT amlazitskaya thinlayerchromatographyintheanalysisofpsychotropicagentsatcombinedpoisoning AT nvchmelevskaya thinlayerchromatographyintheanalysisofpsychotropicagentsatcombinedpoisoning AT eaillarionova thinlayerchromatographyintheanalysisofpsychotropicagentsatcombinedpoisoning
_version_	1718416987419312128

THIN-LAYER CHROMATOGRAPHY IN THE ANALYSIS OF PSYCHOTROPIC AGENTS AT COMBINED POISONING

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