Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children
This study was prepared to identify and characterize potential factors associated with childhood asthma and wheeze in Chinese preschool-aged children. A comprehensive questionnaire was designed for children aged 3–6 years and their parents or guardians in Beijing and Tangshan from September to Decem...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:008cdab88b9e4e9496bded2809758efd2021-11-04T06:31:39ZFactors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children2296-858X10.3389/fmed.2021.742581https://doaj.org/article/008cdab88b9e4e9496bded2809758efd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.742581/fullhttps://doaj.org/toc/2296-858XThis study was prepared to identify and characterize potential factors associated with childhood asthma and wheeze in Chinese preschool-aged children. A comprehensive questionnaire was designed for children aged 3–6 years and their parents or guardians in Beijing and Tangshan from September to December 2020. The least absolute shrinkage and selection operator (LASSO) model was used to identify factors in a significant association with childhood asthma and wheeze, respectively. The LASSO model was internally validated using bootstrap resampling with 100 replications. A total of 9,529 questionnaires were certified as eligible for inclusion after stringent quality control. The prevalence of doctor-diagnosed childhood asthma and parent-reported wheeze was 2.8 and 6.2%, respectively. Factors simultaneously associated with childhood asthma and wheeze were children with a history of allergic rhinitis, hay fever, eczema, initial age of using antibiotics, body mass index category, and family history of asthma. Specifically, children's vitamin D supplement duration was significantly associated with childhood asthma, whereas the association with childhood wheeze was significant for intake frequency of night meals for children and their screen time. Modeling of significant factors in nomograms had decent prediction accuracies, with C-index reaching 0.728 and 0.707 for asthma and wheeze, respectively. In addition, internal validation was good, with bootstrap C-statistic of being 0.736 for asthma and 0.708 for wheeze. Taken together, our findings indicated that the development of asthma and wheeze among preschool-aged children was probably determined by the joint contribution of multiple factors including inherited, nutritional, unhealthy lifestyles, and history of allergic disease. Further validation in other groups is necessary.Xiangling DengXiangling DengMin YangMin YangShunan WangShunan WangQiong WangQiong WangBo PangBo PangKundi WangZhixin ZhangWenquan NiuFrontiers Media S.A.articlechildhood asthmawheezepreschool-aged childrenrisk factorsLASSO regressionnomogramMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
childhood asthma wheeze preschool-aged children risk factors LASSO regression nomogram Medicine (General) R5-920 |
| spellingShingle |
childhood asthma wheeze preschool-aged children risk factors LASSO regression nomogram Medicine (General) R5-920 Xiangling Deng Xiangling Deng Min Yang Min Yang Shunan Wang Shunan Wang Qiong Wang Qiong Wang Bo Pang Bo Pang Kundi Wang Zhixin Zhang Wenquan Niu Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| description |
This study was prepared to identify and characterize potential factors associated with childhood asthma and wheeze in Chinese preschool-aged children. A comprehensive questionnaire was designed for children aged 3–6 years and their parents or guardians in Beijing and Tangshan from September to December 2020. The least absolute shrinkage and selection operator (LASSO) model was used to identify factors in a significant association with childhood asthma and wheeze, respectively. The LASSO model was internally validated using bootstrap resampling with 100 replications. A total of 9,529 questionnaires were certified as eligible for inclusion after stringent quality control. The prevalence of doctor-diagnosed childhood asthma and parent-reported wheeze was 2.8 and 6.2%, respectively. Factors simultaneously associated with childhood asthma and wheeze were children with a history of allergic rhinitis, hay fever, eczema, initial age of using antibiotics, body mass index category, and family history of asthma. Specifically, children's vitamin D supplement duration was significantly associated with childhood asthma, whereas the association with childhood wheeze was significant for intake frequency of night meals for children and their screen time. Modeling of significant factors in nomograms had decent prediction accuracies, with C-index reaching 0.728 and 0.707 for asthma and wheeze, respectively. In addition, internal validation was good, with bootstrap C-statistic of being 0.736 for asthma and 0.708 for wheeze. Taken together, our findings indicated that the development of asthma and wheeze among preschool-aged children was probably determined by the joint contribution of multiple factors including inherited, nutritional, unhealthy lifestyles, and history of allergic disease. Further validation in other groups is necessary. |
| format |
article |
| author |
Xiangling Deng Xiangling Deng Min Yang Min Yang Shunan Wang Shunan Wang Qiong Wang Qiong Wang Bo Pang Bo Pang Kundi Wang Zhixin Zhang Wenquan Niu |
| author_facet |
Xiangling Deng Xiangling Deng Min Yang Min Yang Shunan Wang Shunan Wang Qiong Wang Qiong Wang Bo Pang Bo Pang Kundi Wang Zhixin Zhang Wenquan Niu |
| author_sort |
Xiangling Deng |
| title |
Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| title_short |
Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| title_full |
Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| title_fullStr |
Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| title_full_unstemmed |
Factors Associated With Childhood Asthma and Wheeze in Chinese Preschool-Aged Children |
| title_sort |
factors associated with childhood asthma and wheeze in chinese preschool-aged children |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/008cdab88b9e4e9496bded2809758efd |
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