Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

Gut microbial dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease. Here, the authors examine host-microbiota protein interactions that occur in inflammatory bowel disease; they show an upregulation in proteins related to antimicrobial activities, and alterations in intest...

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Main Authors:	Xu Zhang, Shelley A. Deeke, Zhibin Ning, Amanda E. Starr, James Butcher, Jennifer Li, Janice Mayne, Kai Cheng, Bo Liao, Leyuan Li, Ruth Singleton, David Mack, Alain Stintzi, Daniel Figeys
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/008cdfed823d49f5bf0f351044304ed1
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id	oai:doaj.org-article:008cdfed823d49f5bf0f351044304ed1
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spelling	oai:doaj.org-article:008cdfed823d49f5bf0f351044304ed12021-12-02T16:56:56ZMetaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease10.1038/s41467-018-05357-42041-1723https://doaj.org/article/008cdfed823d49f5bf0f351044304ed12018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05357-4https://doaj.org/toc/2041-1723Gut microbial dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease. Here, the authors examine host-microbiota protein interactions that occur in inflammatory bowel disease; they show an upregulation in proteins related to antimicrobial activities, and alterations in intestinal extracellular vesicles that are associated with aberrant microbiota-interactions.Xu ZhangShelley A. DeekeZhibin NingAmanda E. StarrJames ButcherJennifer LiJanice MayneKai ChengBo LiaoLeyuan LiRuth SingletonDavid MackAlain StintziDaniel FigeysNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xu Zhang Shelley A. Deeke Zhibin Ning Amanda E. Starr James Butcher Jennifer Li Janice Mayne Kai Cheng Bo Liao Leyuan Li Ruth Singleton David Mack Alain Stintzi Daniel Figeys Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
description	Gut microbial dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease. Here, the authors examine host-microbiota protein interactions that occur in inflammatory bowel disease; they show an upregulation in proteins related to antimicrobial activities, and alterations in intestinal extracellular vesicles that are associated with aberrant microbiota-interactions.
format	article
author	Xu Zhang Shelley A. Deeke Zhibin Ning Amanda E. Starr James Butcher Jennifer Li Janice Mayne Kai Cheng Bo Liao Leyuan Li Ruth Singleton David Mack Alain Stintzi Daniel Figeys
author_facet	Xu Zhang Shelley A. Deeke Zhibin Ning Amanda E. Starr James Butcher Jennifer Li Janice Mayne Kai Cheng Bo Liao Leyuan Li Ruth Singleton David Mack Alain Stintzi Daniel Figeys
author_sort	Xu Zhang
title	Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
title_short	Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
title_full	Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
title_fullStr	Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
title_full_unstemmed	Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
title_sort	metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/008cdfed823d49f5bf0f351044304ed1
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Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

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