STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION

Abstract. Pogrammed cell death of peripheral blood mononuclear leucocytes from patients with acute inflammatory diseases (non-nosocomial pneumonia, acute appendicitis) was investigated under ex vivo conditions, upon cultivation of the cells with selective inhibitors of JNK (SP600125) and р38 МАРК (M...

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Autores principales:	N. Y. Chasovskih, N. V. Ryazantseva, E. V. Kaigorodova, O. E. Chechina, E. G. Sokolovich, V. V. Novitskii
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	inflammation apoptosis мар-kinases il-8 il-10 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/008d87c6c0b54dfbb2cf1f41850f34a3
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spelling	oai:doaj.org-article:008d87c6c0b54dfbb2cf1f41850f34a32021-11-18T08:03:40ZSTATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION1563-06252313-741X10.15789/1563-0625-2009-6-515-522https://doaj.org/article/008d87c6c0b54dfbb2cf1f41850f34a32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/353https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Pogrammed cell death of peripheral blood mononuclear leucocytes from patients with acute inflammatory diseases (non-nosocomial pneumonia, acute appendicitis) was investigated under ex vivo conditions, upon cultivation of the cells with selective inhibitors of JNK (SP600125) and р38 МАРК (ML3403). In vitro addition of SP600125 and ML3403 under oxidative stress conditions prevents increase of annexinpositive mononuclear cells numbers, thus suggesting JNK and р38 МАР-kinases to be involved into oxidative mechanisms of apoptosis deregulation. A role of JNK in IL-8 production by mononuclear leucocytes was revealed in cases of acute inflammation. Regulatory effect of JNK and p38 MAP-kinases can be mediated through activation of redox-sensitive apoptogenic signal transduction systems, as well as due to changes in cellular cytokine-producing function.N. Y. ChasovskihN. V. RyazantsevaE. V. KaigorodovaO. E. ChechinaE. G. SokolovichV. V. NovitskiiSPb RAACIarticleinflammationapoptosisмар-kinasesil-8il-10Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 515-522 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	inflammation apoptosis мар-kinases il-8 il-10 Immunologic diseases. Allergy RC581-607
spellingShingle	inflammation apoptosis мар-kinases il-8 il-10 Immunologic diseases. Allergy RC581-607 N. Y. Chasovskih N. V. Ryazantseva E. V. Kaigorodova O. E. Chechina E. G. Sokolovich V. V. Novitskii STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
description	Abstract. Pogrammed cell death of peripheral blood mononuclear leucocytes from patients with acute inflammatory diseases (non-nosocomial pneumonia, acute appendicitis) was investigated under ex vivo conditions, upon cultivation of the cells with selective inhibitors of JNK (SP600125) and р38 МАРК (ML3403). In vitro addition of SP600125 and ML3403 under oxidative stress conditions prevents increase of annexinpositive mononuclear cells numbers, thus suggesting JNK and р38 МАР-kinases to be involved into oxidative mechanisms of apoptosis deregulation. A role of JNK in IL-8 production by mononuclear leucocytes was revealed in cases of acute inflammation. Regulatory effect of JNK and p38 MAP-kinases can be mediated through activation of redox-sensitive apoptogenic signal transduction systems, as well as due to changes in cellular cytokine-producing function.
format	article
author	N. Y. Chasovskih N. V. Ryazantseva E. V. Kaigorodova O. E. Chechina E. G. Sokolovich V. V. Novitskii
author_facet	N. Y. Chasovskih N. V. Ryazantseva E. V. Kaigorodova O. E. Chechina E. G. Sokolovich V. V. Novitskii
author_sort	N. Y. Chasovskih
title	STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
title_short	STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
title_full	STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
title_fullStr	STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
title_full_unstemmed	STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION
title_sort	state of jnk and p38 map-kinase system in blood monon uclea r le ucocytes dur ing inflammation
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/008d87c6c0b54dfbb2cf1f41850f34a3
work_keys_str_mv	AT nychasovskih stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation AT nvryazantseva stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation AT evkaigorodova stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation AT oechechina stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation AT egsokolovich stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation AT vvnovitskii stateofjnkandp38mapkinasesysteminbloodmononuclearleucocytesduringinflammation
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STATE OF JNK AND P38 MAP-KINASE SYSTEM IN BLOOD monon uclea r le ucocytes DUR ING INFLAMMATION

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