In situ structure and organization of the influenza C virus surface glycoprotein

Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to dete...

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Autores principales: Steinar Halldorsson, Kasim Sader, Jack Turner, Lesley J. Calder, Peter B. Rosenthal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/008ebdb450004020b9d7e1709b5330f9
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spelling oai:doaj.org-article:008ebdb450004020b9d7e1709b5330f92021-12-02T11:39:26ZIn situ structure and organization of the influenza C virus surface glycoprotein10.1038/s41467-021-21818-92041-1723https://doaj.org/article/008ebdb450004020b9d7e1709b5330f92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21818-9https://doaj.org/toc/2041-1723Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion.Steinar HalldorssonKasim SaderJack TurnerLesley J. CalderPeter B. RosenthalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Steinar Halldorsson
Kasim Sader
Jack Turner
Lesley J. Calder
Peter B. Rosenthal
In situ structure and organization of the influenza C virus surface glycoprotein
description Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion.
format article
author Steinar Halldorsson
Kasim Sader
Jack Turner
Lesley J. Calder
Peter B. Rosenthal
author_facet Steinar Halldorsson
Kasim Sader
Jack Turner
Lesley J. Calder
Peter B. Rosenthal
author_sort Steinar Halldorsson
title In situ structure and organization of the influenza C virus surface glycoprotein
title_short In situ structure and organization of the influenza C virus surface glycoprotein
title_full In situ structure and organization of the influenza C virus surface glycoprotein
title_fullStr In situ structure and organization of the influenza C virus surface glycoprotein
title_full_unstemmed In situ structure and organization of the influenza C virus surface glycoprotein
title_sort in situ structure and organization of the influenza c virus surface glycoprotein
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/008ebdb450004020b9d7e1709b5330f9
work_keys_str_mv AT steinarhalldorsson insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein
AT kasimsader insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein
AT jackturner insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein
AT lesleyjcalder insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein
AT peterbrosenthal insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein
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