In situ structure and organization of the influenza C virus surface glycoprotein
Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to dete...
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Nature Portfolio
2021
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oai:doaj.org-article:008ebdb450004020b9d7e1709b5330f92021-12-02T11:39:26ZIn situ structure and organization of the influenza C virus surface glycoprotein10.1038/s41467-021-21818-92041-1723https://doaj.org/article/008ebdb450004020b9d7e1709b5330f92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21818-9https://doaj.org/toc/2041-1723Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion.Steinar HalldorssonKasim SaderJack TurnerLesley J. CalderPeter B. RosenthalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
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Science Q Steinar Halldorsson Kasim Sader Jack Turner Lesley J. Calder Peter B. Rosenthal In situ structure and organization of the influenza C virus surface glycoprotein |
description |
Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion. |
format |
article |
author |
Steinar Halldorsson Kasim Sader Jack Turner Lesley J. Calder Peter B. Rosenthal |
author_facet |
Steinar Halldorsson Kasim Sader Jack Turner Lesley J. Calder Peter B. Rosenthal |
author_sort |
Steinar Halldorsson |
title |
In situ structure and organization of the influenza C virus surface glycoprotein |
title_short |
In situ structure and organization of the influenza C virus surface glycoprotein |
title_full |
In situ structure and organization of the influenza C virus surface glycoprotein |
title_fullStr |
In situ structure and organization of the influenza C virus surface glycoprotein |
title_full_unstemmed |
In situ structure and organization of the influenza C virus surface glycoprotein |
title_sort |
in situ structure and organization of the influenza c virus surface glycoprotein |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/008ebdb450004020b9d7e1709b5330f9 |
work_keys_str_mv |
AT steinarhalldorsson insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein AT kasimsader insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein AT jackturner insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein AT lesleyjcalder insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein AT peterbrosenthal insitustructureandorganizationoftheinfluenzacvirussurfaceglycoprotein |
_version_ |
1718395681950924800 |