Towards reliable diagnostics of prostate cancer via breath

Abstract Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attem...

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Auteurs principaux:	K. S. Maiti, E. Fill, F. Strittmatter, Y. Volz, R. Sroka, A. Apolonski
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/0094a73f9d5944e2899ac3767cfb30ae
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id	oai:doaj.org-article:0094a73f9d5944e2899ac3767cfb30ae
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spelling	oai:doaj.org-article:0094a73f9d5944e2899ac3767cfb30ae2021-12-02T15:31:36ZTowards reliable diagnostics of prostate cancer via breath10.1038/s41598-021-96845-z2045-2322https://doaj.org/article/0094a73f9d5944e2899ac3767cfb30ae2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96845-zhttps://doaj.org/toc/2045-2322Abstract Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.K. S. MaitiE. FillF. StrittmatterY. VolzR. SrokaA. ApolonskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. S. Maiti E. Fill F. Strittmatter Y. Volz R. Sroka A. Apolonski Towards reliable diagnostics of prostate cancer via breath
description	Abstract Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.
format	article
author	K. S. Maiti E. Fill F. Strittmatter Y. Volz R. Sroka A. Apolonski
author_facet	K. S. Maiti E. Fill F. Strittmatter Y. Volz R. Sroka A. Apolonski
author_sort	K. S. Maiti
title	Towards reliable diagnostics of prostate cancer via breath
title_short	Towards reliable diagnostics of prostate cancer via breath
title_full	Towards reliable diagnostics of prostate cancer via breath
title_fullStr	Towards reliable diagnostics of prostate cancer via breath
title_full_unstemmed	Towards reliable diagnostics of prostate cancer via breath
title_sort	towards reliable diagnostics of prostate cancer via breath
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0094a73f9d5944e2899ac3767cfb30ae
work_keys_str_mv	AT ksmaiti towardsreliablediagnosticsofprostatecancerviabreath AT efill towardsreliablediagnosticsofprostatecancerviabreath AT fstrittmatter towardsreliablediagnosticsofprostatecancerviabreath AT yvolz towardsreliablediagnosticsofprostatecancerviabreath AT rsroka towardsreliablediagnosticsofprostatecancerviabreath AT aapolonski towardsreliablediagnosticsofprostatecancerviabreath
_version_	1718387123371900928

Towards reliable diagnostics of prostate cancer via breath

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