The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

ABSTRACT ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily...

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Autores principales: Anthony R. Fehr, Rudragouda Channappanavar, Gytis Jankevicius, Craig Fett, Jincun Zhao, Jeremiah Athmer, David K. Meyerholz, Ivan Ahel, Stanley Perlman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/0097247f8f7044de91270e91079a1c7f
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