Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability

Abstract In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed tha...

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Autores principales:	Shiv Bolan, Balaji Seshadri, Simon Keely, Anitha Kunhikrishnan, Jessica Bruce, Ian Grainge, Nicholas J. Talley, Ravi Naidu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0098955b5e324b65be02aada19dac95b
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spelling	oai:doaj.org-article:0098955b5e324b65be02aada19dac95b2021-12-02T17:03:50ZBioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability10.1038/s41598-021-94174-92045-2322https://doaj.org/article/0098955b5e324b65be02aada19dac95b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94174-9https://doaj.org/toc/2045-2322Abstract In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed that in the presence of gut microbes or chelating agents, there was a significant decrease in the permeability of MLs (As-7.5%, Cd-6.3%, Pb-7.9% and Hg-8.2%) as measured by apparent permeability coefficient value (P app), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.Shiv BolanBalaji SeshadriSimon KeelyAnitha KunhikrishnanJessica BruceIan GraingeNicholas J. TalleyRavi NaiduNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiv Bolan Balaji Seshadri Simon Keely Anitha Kunhikrishnan Jessica Bruce Ian Grainge Nicholas J. Talley Ravi Naidu Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
description	Abstract In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed that in the presence of gut microbes or chelating agents, there was a significant decrease in the permeability of MLs (As-7.5%, Cd-6.3%, Pb-7.9% and Hg-8.2%) as measured by apparent permeability coefficient value (P app), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.
format	article
author	Shiv Bolan Balaji Seshadri Simon Keely Anitha Kunhikrishnan Jessica Bruce Ian Grainge Nicholas J. Talley Ravi Naidu
author_facet	Shiv Bolan Balaji Seshadri Simon Keely Anitha Kunhikrishnan Jessica Bruce Ian Grainge Nicholas J. Talley Ravi Naidu
author_sort	Shiv Bolan
title	Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
title_short	Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
title_full	Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
title_fullStr	Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
title_full_unstemmed	Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
title_sort	bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0098955b5e324b65be02aada19dac95b
work_keys_str_mv	AT shivbolan bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT balajiseshadri bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT simonkeely bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT anithakunhikrishnan bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT jessicabruce bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT iangrainge bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT nicholasjtalley bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability AT ravinaidu bioavailabilityofarseniccadmiumleadandmercuryasmeasuredbyintestinalpermeability
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Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability

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