Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide

Mahshid Kalani, Robiah Yunus, Norhafizah AbdullahChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaBackground: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kalani M, Yunus R, Abdullah N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0098be9169c54f0aa4321a8b070e9a41
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0098be9169c54f0aa4321a8b070e9a41
record_format	dspace
spelling	oai:doaj.org-article:0098be9169c54f0aa4321a8b070e9a412021-12-02T07:28:33ZOptimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide1176-91141178-2013https://doaj.org/article/0098be9169c54f0aa4321a8b070e9a412011-05-01T00:00:00Zhttp://www.dovepress.com/optimizing-supercritical-antisolvent-process-parameters-to-minimize-th-a7555https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mahshid Kalani, Robiah Yunus, Norhafizah AbdullahChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaBackground: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation. The interaction between different process parameters was also investigated.Methods and results: The optimized process parameters resulted in production of nanoencapsulated paracetamol in L-polylactide with a mean diameter of approximately 300 nm at 120 bar, 30&deg;C, and a polymer concentration of 16 ppm. Thermogravimetric analysis illustrated the thermal characteristics of the nanoparticles. The high electrical charge on the surface of the nanoparticles caused the particles to repel each other, with the high negative zeta potential preventing flocculation.Conclusion: Our results illustrate the effect of different process parameters on particle size and morphology, and validate results obtained via RSM statistical software. Furthermore, the in vitro drug-release profile is consistent with a Korsmeyer&ndash;Peppas kinetic model.Keywords: supercritical, antisolvent, encapsulation, nanoparticles, biodegradable polymer, optimization, drug deliveryKalani MYunus RAbdullah NDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1101-1105 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kalani M Yunus R Abdullah N Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
description	Mahshid Kalani, Robiah Yunus, Norhafizah AbdullahChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaBackground: The aim of this study was to optimize the different process parameters including pressure, temperature, and polymer concentration, to produce fine small spherical particles with a narrow particle size distribution using a supercritical antisolvent method for drug encapsulation. The interaction between different process parameters was also investigated.Methods and results: The optimized process parameters resulted in production of nanoencapsulated paracetamol in L-polylactide with a mean diameter of approximately 300 nm at 120 bar, 30&deg;C, and a polymer concentration of 16 ppm. Thermogravimetric analysis illustrated the thermal characteristics of the nanoparticles. The high electrical charge on the surface of the nanoparticles caused the particles to repel each other, with the high negative zeta potential preventing flocculation.Conclusion: Our results illustrate the effect of different process parameters on particle size and morphology, and validate results obtained via RSM statistical software. Furthermore, the in vitro drug-release profile is consistent with a Korsmeyer&ndash;Peppas kinetic model.Keywords: supercritical, antisolvent, encapsulation, nanoparticles, biodegradable polymer, optimization, drug delivery
format	article
author	Kalani M Yunus R Abdullah N
author_facet	Kalani M Yunus R Abdullah N
author_sort	Kalani M
title	Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
title_short	Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
title_full	Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
title_fullStr	Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
title_full_unstemmed	Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide
title_sort	optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in l-polylactide
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/0098be9169c54f0aa4321a8b070e9a41
work_keys_str_mv	AT kalanim optimizingsupercriticalantisolventprocessparameterstominimizetheparticlesizeofparacetamolnanoencapsulatedinlpolylactide AT yunusr optimizingsupercriticalantisolventprocessparameterstominimizetheparticlesizeofparacetamolnanoencapsulatedinlpolylactide AT abdullahn optimizingsupercriticalantisolventprocessparameterstominimizetheparticlesizeofparacetamolnanoencapsulatedinlpolylactide
_version_	1718399379473170432

Optimizing supercritical antisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide

Ejemplares similares