Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.

<h4>Background</h4>Little is known about the epidemiology of nosocomial bloodstream infections in public hospitals in developing countries. We evaluated trends in incidence of hospital-acquired bacteremia (HAB) and healthcare-associated bacteremia (HCAB) and associated mortality in a dev...

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Autores principales:	Maliwan Hongsuwan, Pramot Srisamang, Manas Kanoksil, Nantasit Luangasanatip, Anchalee Jatapai, Nicholas P Day, Sharon J Peacock, Ben S Cooper, Direk Limmathurotsakul
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0098d450d1a14bc3be0431f386b03723
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spelling	oai:doaj.org-article:0098d450d1a14bc3be0431f386b037232021-11-25T05:56:52ZIncreasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.1932-620310.1371/journal.pone.0109324https://doaj.org/article/0098d450d1a14bc3be0431f386b037232014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109324https://doaj.org/toc/1932-6203<h4>Background</h4>Little is known about the epidemiology of nosocomial bloodstream infections in public hospitals in developing countries. We evaluated trends in incidence of hospital-acquired bacteremia (HAB) and healthcare-associated bacteremia (HCAB) and associated mortality in a developing country using routinely available databases.<h4>Methods</h4>Information from the microbiology and hospital databases of 10 provincial hospitals in northeast Thailand was linked with the national death registry for 2004-2010. Bacteremia was considered hospital-acquired if detected after the first two days of hospital admission, and healthcare-associated if detected within two days of hospital admission with a prior inpatient episode in the preceding 30 days.<h4>Results</h4>A total of 3,424 patients out of 1,069,443 at risk developed HAB and 2,184 out of 119,286 at risk had HCAB. Of these 1,559 (45.5%) and 913 (41.8%) died within 30 days, respectively. Between 2004 and 2010, the incidence rate of HAB increased from 0.6 to 0.8 per 1,000 patient-days at risk (p<0.001), and the cumulative incidence of HCAB increased from 1.2 to 2.0 per 100 readmissions (p<0.001). The most common causes of HAB were Acinetobacter spp. (16.2%), Klebsiella pneumoniae (13.9%), and Staphylococcus aureus (13.9%), while those of HCAB were Escherichia coli (26.3%), S. aureus (14.0%), and K. pneumoniae (9.7%). There was an overall increase over time in the proportions of ESBL-producing E. coli causing HAB and HCAB.<h4>Conclusions</h4>This study demonstrates a high and increasing incidence of HAB and HCAB in provincial hospitals in northeast Thailand, increasing proportions of ESBL-producing isolates, and very high associated mortality.Maliwan HongsuwanPramot SrisamangManas KanoksilNantasit LuangasanatipAnchalee JatapaiNicholas P DaySharon J PeacockBen S CooperDirek LimmathurotsakulPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109324 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maliwan Hongsuwan Pramot Srisamang Manas Kanoksil Nantasit Luangasanatip Anchalee Jatapai Nicholas P Day Sharon J Peacock Ben S Cooper Direk Limmathurotsakul Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
description	<h4>Background</h4>Little is known about the epidemiology of nosocomial bloodstream infections in public hospitals in developing countries. We evaluated trends in incidence of hospital-acquired bacteremia (HAB) and healthcare-associated bacteremia (HCAB) and associated mortality in a developing country using routinely available databases.<h4>Methods</h4>Information from the microbiology and hospital databases of 10 provincial hospitals in northeast Thailand was linked with the national death registry for 2004-2010. Bacteremia was considered hospital-acquired if detected after the first two days of hospital admission, and healthcare-associated if detected within two days of hospital admission with a prior inpatient episode in the preceding 30 days.<h4>Results</h4>A total of 3,424 patients out of 1,069,443 at risk developed HAB and 2,184 out of 119,286 at risk had HCAB. Of these 1,559 (45.5%) and 913 (41.8%) died within 30 days, respectively. Between 2004 and 2010, the incidence rate of HAB increased from 0.6 to 0.8 per 1,000 patient-days at risk (p<0.001), and the cumulative incidence of HCAB increased from 1.2 to 2.0 per 100 readmissions (p<0.001). The most common causes of HAB were Acinetobacter spp. (16.2%), Klebsiella pneumoniae (13.9%), and Staphylococcus aureus (13.9%), while those of HCAB were Escherichia coli (26.3%), S. aureus (14.0%), and K. pneumoniae (9.7%). There was an overall increase over time in the proportions of ESBL-producing E. coli causing HAB and HCAB.<h4>Conclusions</h4>This study demonstrates a high and increasing incidence of HAB and HCAB in provincial hospitals in northeast Thailand, increasing proportions of ESBL-producing isolates, and very high associated mortality.
format	article
author	Maliwan Hongsuwan Pramot Srisamang Manas Kanoksil Nantasit Luangasanatip Anchalee Jatapai Nicholas P Day Sharon J Peacock Ben S Cooper Direk Limmathurotsakul
author_facet	Maliwan Hongsuwan Pramot Srisamang Manas Kanoksil Nantasit Luangasanatip Anchalee Jatapai Nicholas P Day Sharon J Peacock Ben S Cooper Direk Limmathurotsakul
author_sort	Maliwan Hongsuwan
title	Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
title_short	Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
title_full	Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
title_fullStr	Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
title_full_unstemmed	Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.
title_sort	increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast thailand: a multicenter surveillance study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0098d450d1a14bc3be0431f386b03723
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Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study.

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