Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.
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Nature Portfolio
2020
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oai:doaj.org-article:009c5504e81841cb823079d832c9273c2021-12-02T18:48:25ZMultiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma10.1038/s41467-020-18582-72041-1723https://doaj.org/article/009c5504e81841cb823079d832c9273c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18582-7https://doaj.org/toc/2041-1723Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.Stephen T. MagillHarish N. VasudevanKyounghee SeoJavier E. Villanueva-MeyerAbrar ChoudhuryS. John LiuMelike PekmezciSarah FindaklyStephanie HilzSydney LastellaBenjamin DemareeSteve E. BraunsteinNancy Ann Oberheim BushManish K. AghiPhilip V. TheodosopoulosPenny K. SneedAdam R. AbateMitchel S. BergerMichael W. McDermottDaniel A. LimErik M. UllianJoseph F. CostelloDavid R. RaleighNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Stephen T. Magill Harish N. Vasudevan Kyounghee Seo Javier E. Villanueva-Meyer Abrar Choudhury S. John Liu Melike Pekmezci Sarah Findakly Stephanie Hilz Sydney Lastella Benjamin Demaree Steve E. Braunstein Nancy Ann Oberheim Bush Manish K. Aghi Philip V. Theodosopoulos Penny K. Sneed Adam R. Abate Mitchel S. Berger Michael W. McDermott Daniel A. Lim Erik M. Ullian Joseph F. Costello David R. Raleigh Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| description |
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging. |
| format |
article |
| author |
Stephen T. Magill Harish N. Vasudevan Kyounghee Seo Javier E. Villanueva-Meyer Abrar Choudhury S. John Liu Melike Pekmezci Sarah Findakly Stephanie Hilz Sydney Lastella Benjamin Demaree Steve E. Braunstein Nancy Ann Oberheim Bush Manish K. Aghi Philip V. Theodosopoulos Penny K. Sneed Adam R. Abate Mitchel S. Berger Michael W. McDermott Daniel A. Lim Erik M. Ullian Joseph F. Costello David R. Raleigh |
| author_facet |
Stephen T. Magill Harish N. Vasudevan Kyounghee Seo Javier E. Villanueva-Meyer Abrar Choudhury S. John Liu Melike Pekmezci Sarah Findakly Stephanie Hilz Sydney Lastella Benjamin Demaree Steve E. Braunstein Nancy Ann Oberheim Bush Manish K. Aghi Philip V. Theodosopoulos Penny K. Sneed Adam R. Abate Mitchel S. Berger Michael W. McDermott Daniel A. Lim Erik M. Ullian Joseph F. Costello David R. Raleigh |
| author_sort |
Stephen T. Magill |
| title |
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| title_short |
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| title_full |
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| title_fullStr |
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| title_full_unstemmed |
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| title_sort |
multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/009c5504e81841cb823079d832c9273c |
| work_keys_str_mv |
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1718377601997733888 |