ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein pathway may be a therapeutic target in these tumour...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christine M. Hoeman, Francisco J. Cordero, Guo Hu, Katie Misuraca, Megan M. Romero, Herminio J. Cardona, Javad Nazarian, Rintaro Hashizume, Roger McLendon, Paul Yu, Daniele Procissi, Samantha Gadd, Oren J. Becher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:00a70d4e9ad84bf1a869249303aa2d30
record_format	dspace
spelling	oai:doaj.org-article:00a70d4e9ad84bf1a869249303aa2d302021-12-02T15:36:03ZACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis10.1038/s41467-019-08823-92041-1723https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d302019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08823-9https://doaj.org/toc/2041-1723ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein pathway may be a therapeutic target in these tumours.Christine M. HoemanFrancisco J. CorderoGuo HuKatie MisuracaMegan M. RomeroHerminio J. CardonaJavad NazarianRintaro HashizumeRoger McLendonPaul YuDaniele ProcissiSamantha GaddOren J. BecherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine M. Hoeman Francisco J. Cordero Guo Hu Katie Misuraca Megan M. Romero Herminio J. Cardona Javad Nazarian Rintaro Hashizume Roger McLendon Paul Yu Daniele Procissi Samantha Gadd Oren J. Becher ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
description	ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein pathway may be a therapeutic target in these tumours.
format	article
author	Christine M. Hoeman Francisco J. Cordero Guo Hu Katie Misuraca Megan M. Romero Herminio J. Cardona Javad Nazarian Rintaro Hashizume Roger McLendon Paul Yu Daniele Procissi Samantha Gadd Oren J. Becher
author_facet	Christine M. Hoeman Francisco J. Cordero Guo Hu Katie Misuraca Megan M. Romero Herminio J. Cardona Javad Nazarian Rintaro Hashizume Roger McLendon Paul Yu Daniele Procissi Samantha Gadd Oren J. Becher
author_sort	Christine M. Hoeman
title	ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
title_short	ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
title_full	ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
title_fullStr	ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
title_full_unstemmed	ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
title_sort	acvr1 r206h cooperates with h3.1k27m in promoting diffuse intrinsic pontine glioma pathogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d30
work_keys_str_mv	AT christinemhoeman acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT franciscojcordero acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT guohu acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT katiemisuraca acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT meganmromero acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT herminiojcardona acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT javadnazarian acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT rintarohashizume acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT rogermclendon acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT paulyu acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT danieleprocissi acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT samanthagadd acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis AT orenjbecher acvr1r206hcooperateswithh31k27minpromotingdiffuseintrinsicpontinegliomapathogenesis
_version_	1718386331807121408

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Ejemplares similares