ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein pathway may be a therapeutic target in these tumour...
Guardado en:
Autores principales: | Christine M. Hoeman, Francisco J. Cordero, Guo Hu, Katie Misuraca, Megan M. Romero, Herminio J. Cardona, Javad Nazarian, Rintaro Hashizume, Roger McLendon, Paul Yu, Daniele Procissi, Samantha Gadd, Oren J. Becher |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d30 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A case of Fibrodysplasia Ossificans Progressiva associated with a novel variant of the ACVR1 gene
por: Serena Cappato, et al.
Publicado: (2021) -
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy
por: Young Suk Yu, et al.
Publicado: (2020) -
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
por: Hamid Nikbakht, et al.
Publicado: (2016) -
Fibrodisplasia osificante progresiva plus por una variante patogénica del gen ACVR1: Caso clínico
por: Contreras-Olea,Oscar, et al.
Publicado: (2019) -
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis
por: Diana Monsivais, et al.
Publicado: (2021)