MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu

Background: Invariant natural killer T cells (iNKT ) can be activated by certain types of glycolipids that have the potential to generate adjuvant effects which could be used to develop effective and safe immunotherapies. Many of these glycolipids have been isolated from natural organisms, but there...

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Autores principales:	Andrés BAENA, Lina GÓMEZ-GIRALDO, Wilton A GÓMEZ, Carlos A PELÁEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2015
Materias:	iNKT s Glicolípidos CD1d Líquenes Adyuvante Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/00a75f4cd3a94b58886f5642df7ea08b
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spelling	oai:doaj.org-article:00a75f4cd3a94b58886f5642df7ea08b2021-12-02T06:56:51ZMURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu0121-400410.17533/udea.vitae.v22n1a02https://doaj.org/article/00a75f4cd3a94b58886f5642df7ea08b2015-04-01T00:00:00Zhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042015000100002&lng=en&tlng=enhttps://doaj.org/toc/0121-4004Background: Invariant natural killer T cells (iNKT ) can be activated by certain types of glycolipids that have the potential to generate adjuvant effects which could be used to develop effective and safe immunotherapies. Many of these glycolipids have been isolated from natural organisms, but there is a great amount of these organisms completely unexplored as a source of these types of compounds. Some of these organisms are lichens which are complex symbiotic organisms that have been showed to contain glycolipids. Objectives: We decide to test if glycolipids isolated from lichens would be able to activate iNKT cells in vitro and in vivo. Methods: We have used extracted glycolipids from 43 different species of lichens from Colombia. We have used iNKT hybridoma cells, C57BL/6 mice, IL-2 ELISA and the B16 melanoma to test for the adjuvant capabilities of glycolipids isolated from lichens. Results: In this study we have found two glycolipids with the capacity to activate iNKT cells in vitro. One of the glycolipids was able to activate iNKT cells in vivo, and was competent to induce protection against the B16 melanoma in the mouse model. Conclusions: We propose a possible chemical structure for a novel glycolipid called β-GalCer-lich (1) derived from the lichen Stereocaulon ramulosum.Andrés BAENALina GÓMEZ-GIRALDOWilton A GÓMEZCarlos A PELÁEZUniversidad de AntioquiaarticleiNKT sGlicolípidosCD1dLíquenesAdyuvanteFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 22, Iss 1, Pp 13-26 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	iNKT s Glicolípidos CD1d Líquenes Adyuvante Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	iNKT s Glicolípidos CD1d Líquenes Adyuvante Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Andrés BAENA Lina GÓMEZ-GIRALDO Wilton A GÓMEZ Carlos A PELÁEZ MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
description	Background: Invariant natural killer T cells (iNKT ) can be activated by certain types of glycolipids that have the potential to generate adjuvant effects which could be used to develop effective and safe immunotherapies. Many of these glycolipids have been isolated from natural organisms, but there is a great amount of these organisms completely unexplored as a source of these types of compounds. Some of these organisms are lichens which are complex symbiotic organisms that have been showed to contain glycolipids. Objectives: We decide to test if glycolipids isolated from lichens would be able to activate iNKT cells in vitro and in vivo. Methods: We have used extracted glycolipids from 43 different species of lichens from Colombia. We have used iNKT hybridoma cells, C57BL/6 mice, IL-2 ELISA and the B16 melanoma to test for the adjuvant capabilities of glycolipids isolated from lichens. Results: In this study we have found two glycolipids with the capacity to activate iNKT cells in vitro. One of the glycolipids was able to activate iNKT cells in vivo, and was competent to induce protection against the B16 melanoma in the mouse model. Conclusions: We propose a possible chemical structure for a novel glycolipid called β-GalCer-lich (1) derived from the lichen Stereocaulon ramulosum.
format	article
author	Andrés BAENA Lina GÓMEZ-GIRALDO Wilton A GÓMEZ Carlos A PELÁEZ
author_facet	Andrés BAENA Lina GÓMEZ-GIRALDO Wilton A GÓMEZ Carlos A PELÁEZ
author_sort	Andrés BAENA
title	MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
title_short	MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
title_full	MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
title_fullStr	MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
title_full_unstemmed	MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu
title_sort	murine invariant natural killer t cells recognize glycolipids derived from extrac ts of the lichen stereocaulon ramulosu
publisher	Universidad de Antioquia
publishDate	2015
url	https://doaj.org/article/00a75f4cd3a94b58886f5642df7ea08b
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MURINE INVARIANT NATURAL KILLER T CELLS RECOGNIZE GLYCOLIPIDS DERIVED FROM EXTRAC TS OF THE LICHEN Stereocaulon ramulosu

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