A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae

Hoshino et al. show that PTH3, the S. cerevisiae homolog of C12orf65, is required for the translation of mitochondrial genes in the presence of antibiotics. This study suggests that PTH3 rescues the ribosomes stalled by antibiotics, playing a role in antibiotic resistance in fungi.

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Autores principales:	Soichiro Hoshino, Ryohei Kanemura, Daisuke Kurita, Yukihiro Soutome, Hyouta Himeno, Masak Takaine, Masakatsu Watanabe, Nobukazu Nameki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/00aad6f4ead54b9485ea6826cd9557f7
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spelling	oai:doaj.org-article:00aad6f4ead54b9485ea6826cd9557f72021-12-02T15:52:40ZA stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae10.1038/s42003-021-01835-62399-3642https://doaj.org/article/00aad6f4ead54b9485ea6826cd9557f72021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01835-6https://doaj.org/toc/2399-3642Hoshino et al. show that PTH3, the S. cerevisiae homolog of C12orf65, is required for the translation of mitochondrial genes in the presence of antibiotics. This study suggests that PTH3 rescues the ribosomes stalled by antibiotics, playing a role in antibiotic resistance in fungi.Soichiro HoshinoRyohei KanemuraDaisuke KuritaYukihiro SoutomeHyouta HimenoMasak TakaineMasakatsu WatanabeNobukazu NamekiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Soichiro Hoshino Ryohei Kanemura Daisuke Kurita Yukihiro Soutome Hyouta Himeno Masak Takaine Masakatsu Watanabe Nobukazu Nameki A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
description	Hoshino et al. show that PTH3, the S. cerevisiae homolog of C12orf65, is required for the translation of mitochondrial genes in the presence of antibiotics. This study suggests that PTH3 rescues the ribosomes stalled by antibiotics, playing a role in antibiotic resistance in fungi.
format	article
author	Soichiro Hoshino Ryohei Kanemura Daisuke Kurita Yukihiro Soutome Hyouta Himeno Masak Takaine Masakatsu Watanabe Nobukazu Nameki
author_facet	Soichiro Hoshino Ryohei Kanemura Daisuke Kurita Yukihiro Soutome Hyouta Himeno Masak Takaine Masakatsu Watanabe Nobukazu Nameki
author_sort	Soichiro Hoshino
title	A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
title_short	A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
title_full	A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
title_fullStr	A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
title_full_unstemmed	A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
title_sort	stalled-ribosome rescue factor pth3 is required for mitochondrial translation against antibiotics in saccharomyces cerevisiae
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00aad6f4ead54b9485ea6826cd9557f7
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A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae

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