Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study

Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known to modulate the redox status of the cell and has i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhigang Liu, Ishan Patil, Harsh Sancheti, Fei Yin, Enrique Cadenas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00abb3e70d59446397a7d5cea45acd64
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:00abb3e70d59446397a7d5cea45acd64
record_format	dspace
spelling	oai:doaj.org-article:00abb3e70d59446397a7d5cea45acd642021-12-02T16:06:06ZEffects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study10.1038/s41598-017-05217-z2045-2322https://doaj.org/article/00abb3e70d59446397a7d5cea45acd642017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05217-zhttps://doaj.org/toc/2045-2322Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects. This study was aimed at determining the effects of dietary administration of lipoic acid on a HFD-induced obesity model in terms of (a) insulin signaling, (b) brain glucose uptake and neuronal- and astrocytic metabolism, and (c) synaptic plasticity. 3-Month old C57BL/6J mice were divided into 4 groups exposed to their respective treatments for 9 weeks: (1) normal diet, (2) normal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid. HFD resulted in higher body weight, development of insulin resistance, lower brain glucose uptake and glucose transporters, alterations in glycolytic and acetate metabolism in neurons and astrocytes, and ultimately synaptic plasticity loss evident by a decreased long-term potentiation (LTP). Lipoic acid treatment in mice on HFD prevented several HFD-induced metabolic changes and preserved synaptic plasticity. The metabolic and physiological changes in HFD-fed mice, including insulin resistance, brain glucose uptake and metabolism, and synaptic function, could be preserved by the insulin-like effect of lipoic acid.Zhigang LiuIshan PatilHarsh SanchetiFei YinEnrique CadenasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhigang Liu Ishan Patil Harsh Sancheti Fei Yin Enrique Cadenas Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
description	Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects. This study was aimed at determining the effects of dietary administration of lipoic acid on a HFD-induced obesity model in terms of (a) insulin signaling, (b) brain glucose uptake and neuronal- and astrocytic metabolism, and (c) synaptic plasticity. 3-Month old C57BL/6J mice were divided into 4 groups exposed to their respective treatments for 9 weeks: (1) normal diet, (2) normal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid. HFD resulted in higher body weight, development of insulin resistance, lower brain glucose uptake and glucose transporters, alterations in glycolytic and acetate metabolism in neurons and astrocytes, and ultimately synaptic plasticity loss evident by a decreased long-term potentiation (LTP). Lipoic acid treatment in mice on HFD prevented several HFD-induced metabolic changes and preserved synaptic plasticity. The metabolic and physiological changes in HFD-fed mice, including insulin resistance, brain glucose uptake and metabolism, and synaptic function, could be preserved by the insulin-like effect of lipoic acid.
format	article
author	Zhigang Liu Ishan Patil Harsh Sancheti Fei Yin Enrique Cadenas
author_facet	Zhigang Liu Ishan Patil Harsh Sancheti Fei Yin Enrique Cadenas
author_sort	Zhigang Liu
title	Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
title_short	Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
title_full	Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
title_fullStr	Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
title_full_unstemmed	Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
title_sort	effects of lipoic acid on high-fat diet-induced alteration of synaptic plasticity and brain glucose metabolism: a pet/ct and 13c-nmr study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00abb3e70d59446397a7d5cea45acd64
work_keys_str_mv	AT zhigangliu effectsoflipoicacidonhighfatdietinducedalterationofsynapticplasticityandbrainglucosemetabolismapetctand13cnmrstudy AT ishanpatil effectsoflipoicacidonhighfatdietinducedalterationofsynapticplasticityandbrainglucosemetabolismapetctand13cnmrstudy AT harshsancheti effectsoflipoicacidonhighfatdietinducedalterationofsynapticplasticityandbrainglucosemetabolismapetctand13cnmrstudy AT feiyin effectsoflipoicacidonhighfatdietinducedalterationofsynapticplasticityandbrainglucosemetabolismapetctand13cnmrstudy AT enriquecadenas effectsoflipoicacidonhighfatdietinducedalterationofsynapticplasticityandbrainglucosemetabolismapetctand13cnmrstudy
_version_	1718385066008117248

Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study

Ejemplares similares