Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein

Custodio et al. characterise a mouse model of ADHD in which thyroid hormone-responsive protein is overexpressed. They demonstrate that reduced levels of striatal triiodothyronine (T3) play a role in inattention and memory impairment in this model and that the model could be used in future studies ex...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Raly James Perez Custodio, Mikyung Kim, Leandro Val Sayson, Hyun Jun Lee, Darlene Mae Ortiz, Bung-Nyun Kim, Hee Jin Kim, Jae Hoon Cheong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/00b6ecf38cbd49f8874762ca99aa5506
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:00b6ecf38cbd49f8874762ca99aa5506
record_format	dspace
spelling	oai:doaj.org-article:00b6ecf38cbd49f8874762ca99aa55062021-12-02T18:48:42ZLow striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein10.1038/s42003-021-02633-w2399-3642https://doaj.org/article/00b6ecf38cbd49f8874762ca99aa55062021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02633-whttps://doaj.org/toc/2399-3642Custodio et al. characterise a mouse model of ADHD in which thyroid hormone-responsive protein is overexpressed. They demonstrate that reduced levels of striatal triiodothyronine (T3) play a role in inattention and memory impairment in this model and that the model could be used in future studies examining the predominantly inattentive subtype of ADHD.Raly James Perez CustodioMikyung KimLeandro Val SaysonHyun Jun LeeDarlene Mae OrtizBung-Nyun KimHee Jin KimJae Hoon CheongNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Raly James Perez Custodio Mikyung Kim Leandro Val Sayson Hyun Jun Lee Darlene Mae Ortiz Bung-Nyun Kim Hee Jin Kim Jae Hoon Cheong Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
description	Custodio et al. characterise a mouse model of ADHD in which thyroid hormone-responsive protein is overexpressed. They demonstrate that reduced levels of striatal triiodothyronine (T3) play a role in inattention and memory impairment in this model and that the model could be used in future studies examining the predominantly inattentive subtype of ADHD.
format	article
author	Raly James Perez Custodio Mikyung Kim Leandro Val Sayson Hyun Jun Lee Darlene Mae Ortiz Bung-Nyun Kim Hee Jin Kim Jae Hoon Cheong
author_facet	Raly James Perez Custodio Mikyung Kim Leandro Val Sayson Hyun Jun Lee Darlene Mae Ortiz Bung-Nyun Kim Hee Jin Kim Jae Hoon Cheong
author_sort	Raly James Perez Custodio
title	Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
title_short	Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
title_full	Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
title_fullStr	Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
title_full_unstemmed	Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
title_sort	low striatal t3 is implicated in inattention and memory impairment in an adhd mouse model overexpressing thyroid hormone-responsive protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00b6ecf38cbd49f8874762ca99aa5506
work_keys_str_mv	AT ralyjamesperezcustodio lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT mikyungkim lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT leandrovalsayson lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT hyunjunlee lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT darlenemaeortiz lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT bungnyunkim lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT heejinkim lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein AT jaehooncheong lowstriatalt3isimplicatedininattentionandmemoryimpairmentinanadhdmousemodeloverexpressingthyroidhormoneresponsiveprotein
_version_	1718377543155843072

Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein

Ejemplares similares