Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina

Abstract Transorbital electrical stimulation (tES) has been studied as a new noninvasive method for treating intractable eye diseases by delivering weak electrical current to the eye through a pair of electrodes attached to the skin around the eye. Studies have reported that the therapeutic effect o...

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Autores principales:	Sangjun Lee, Jimin Park, Jinuk Kwon, Dong Hwan Kim, Chang-Hwan Im
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/00b90712c6fc49e08fae112cd2583b87
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spelling	oai:doaj.org-article:00b90712c6fc49e08fae112cd2583b872021-12-02T14:42:53ZMulti-channel transorbital electrical stimulation for effective stimulation of posterior retina10.1038/s41598-021-89243-y2045-2322https://doaj.org/article/00b90712c6fc49e08fae112cd2583b872021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89243-yhttps://doaj.org/toc/2045-2322Abstract Transorbital electrical stimulation (tES) has been studied as a new noninvasive method for treating intractable eye diseases by delivering weak electrical current to the eye through a pair of electrodes attached to the skin around the eye. Studies have reported that the therapeutic effect of tES is determined by the effective stimulation of retinal cells that are densely distributed in the posterior part of the retina. However, in conventional tES with a pair of electrodes, a greater portion of the electric field is delivered to the anterior part of the retina. In this study, to address this issue, a new electrode montage with multiple electrodes was proposed for the effective delivery of electric fields to the posterior retina. Electric field analysis based on the finite element method was performed with a realistic human head model, and optimal injection currents were determined using constrained convex optimization. The resultant electric field distributions showed that the proposed multi-channel tES enables a more effective stimulation of the posterior retina than the conventional tES with a pair of electrodes.Sangjun LeeJimin ParkJinuk KwonDong Hwan KimChang-Hwan ImNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sangjun Lee Jimin Park Jinuk Kwon Dong Hwan Kim Chang-Hwan Im Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
description	Abstract Transorbital electrical stimulation (tES) has been studied as a new noninvasive method for treating intractable eye diseases by delivering weak electrical current to the eye through a pair of electrodes attached to the skin around the eye. Studies have reported that the therapeutic effect of tES is determined by the effective stimulation of retinal cells that are densely distributed in the posterior part of the retina. However, in conventional tES with a pair of electrodes, a greater portion of the electric field is delivered to the anterior part of the retina. In this study, to address this issue, a new electrode montage with multiple electrodes was proposed for the effective delivery of electric fields to the posterior retina. Electric field analysis based on the finite element method was performed with a realistic human head model, and optimal injection currents were determined using constrained convex optimization. The resultant electric field distributions showed that the proposed multi-channel tES enables a more effective stimulation of the posterior retina than the conventional tES with a pair of electrodes.
format	article
author	Sangjun Lee Jimin Park Jinuk Kwon Dong Hwan Kim Chang-Hwan Im
author_facet	Sangjun Lee Jimin Park Jinuk Kwon Dong Hwan Kim Chang-Hwan Im
author_sort	Sangjun Lee
title	Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
title_short	Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
title_full	Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
title_fullStr	Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
title_full_unstemmed	Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
title_sort	multi-channel transorbital electrical stimulation for effective stimulation of posterior retina
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/00b90712c6fc49e08fae112cd2583b87
work_keys_str_mv	AT sangjunlee multichanneltransorbitalelectricalstimulationforeffectivestimulationofposteriorretina AT jiminpark multichanneltransorbitalelectricalstimulationforeffectivestimulationofposteriorretina AT jinukkwon multichanneltransorbitalelectricalstimulationforeffectivestimulationofposteriorretina AT donghwankim multichanneltransorbitalelectricalstimulationforeffectivestimulationofposteriorretina AT changhwanim multichanneltransorbitalelectricalstimulationforeffectivestimulationofposteriorretina
_version_	1718389547964825600

Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina

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