Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes

The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical...

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Autores principales:	Gulnara SHAKIRZYANOVA, Liliya ROMANOVA, Bahrom BABAEV, Vladimir АBDUKACHAROV, Tulkun ISKANDAROV, Sabina GAYIBOVA
Formato:	article
Lenguaje:	EN SL
Publicado:	University of Ljubljana, Biotechnical Faculty 2021
Materias:	l-proline aggregation pheromone sitophilure aldol condensation pest insect, toxicological indexes Agriculture S
Acceso en línea:	https://doaj.org/article/00c35be0ffc044ce929f4ea32b651583
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spelling	oai:doaj.org-article:00c35be0ffc044ce929f4ea32b6515832021-11-10T09:25:10ZSynthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes1581-91751854-194110.14720/aas.2021.117.2.1961https://doaj.org/article/00c35be0ffc044ce929f4ea32b6515832021-07-01T00:00:00Zhttp://ojs.aas.bf.uni-lj.si/index.php/AAS/article/view/1961https://doaj.org/toc/1581-9175https://doaj.org/toc/1854-1941The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical pesticides. The average lethal dose of the product per orally administered to the white mice was established to be 4375.0 mg kg-1 LD16 and LD84 being 2225.0 mg kg-1 and 6550.0 mg kg-1, respectively. The average lethal dose for rabbits was 5900.0 mg kg-1 5-hydroxy-4-methyl-3-heptanone proved to have a mild skin and conjunctival irritant action, and equally mild functional cumulation. As to chronic toxicity, the acceptable daily dose of 4.3 mg/person/d was calculated and scientifically substantiated. The odor threshold was determined at the dose ranging from 0.35 to 0.7 mg l-1 with the practical limit ranging from 0.35 to 1.5 mg l-1, taste sensation threshold was found at the dose ranging from 1.0 to 3.0 mg l-1 with the practical limit ranging from 3.0 to 7.0 mg l-1Gulnara SHAKIRZYANOVALiliya ROMANOVABahrom BABAEVVladimir АBDUKACHAROVTulkun ISKANDAROVSabina GAYIBOVAUniversity of Ljubljana, Biotechnical Facultyarticlel-prolineaggregation pheromonesitophilurealdol condensationpest insect, toxicological indexesAgricultureSENSLActa Agriculturae Slovenica, Vol 117, Iss 2, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN SL
topic	l-proline aggregation pheromone sitophilure aldol condensation pest insect, toxicological indexes Agriculture S
spellingShingle	l-proline aggregation pheromone sitophilure aldol condensation pest insect, toxicological indexes Agriculture S Gulnara SHAKIRZYANOVA Liliya ROMANOVA Bahrom BABAEV Vladimir АBDUKACHAROV Tulkun ISKANDAROV Sabina GAYIBOVA Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
description	The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical pesticides. The average lethal dose of the product per orally administered to the white mice was established to be 4375.0 mg kg-1 LD16 and LD84 being 2225.0 mg kg-1 and 6550.0 mg kg-1, respectively. The average lethal dose for rabbits was 5900.0 mg kg-1 5-hydroxy-4-methyl-3-heptanone proved to have a mild skin and conjunctival irritant action, and equally mild functional cumulation. As to chronic toxicity, the acceptable daily dose of 4.3 mg/person/d was calculated and scientifically substantiated. The odor threshold was determined at the dose ranging from 0.35 to 0.7 mg l-1 with the practical limit ranging from 0.35 to 1.5 mg l-1, taste sensation threshold was found at the dose ranging from 1.0 to 3.0 mg l-1 with the practical limit ranging from 3.0 to 7.0 mg l-1
format	article
author	Gulnara SHAKIRZYANOVA Liliya ROMANOVA Bahrom BABAEV Vladimir АBDUKACHAROV Tulkun ISKANDAROV Sabina GAYIBOVA
author_facet	Gulnara SHAKIRZYANOVA Liliya ROMANOVA Bahrom BABAEV Vladimir АBDUKACHAROV Tulkun ISKANDAROV Sabina GAYIBOVA
author_sort	Gulnara SHAKIRZYANOVA
title	Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
title_short	Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
title_full	Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
title_fullStr	Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
title_full_unstemmed	Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
title_sort	synthesis of a synthetic analogue for the sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes
publisher	University of Ljubljana, Biotechnical Faculty
publishDate	2021
url	https://doaj.org/article/00c35be0ffc044ce929f4ea32b651583
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Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes

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